血清和腹腔液CA125测定与子宫内膜异位症诊断的相关分析

目的:探讨不孕症患者术前血清及术中腹腔液CA125浓度与诊断子宫内膜异位症(EM)的关系。方法:对129例因疑输卵管性不孕而行腹腔镜或宫腹腔镜联合手术的患者,于术前抽取血清,术中抽取腹腔液测CA125浓度。根据血清CA125值分为<10U/ml、10-15U/ml、16-34U/ml和≥35U/ml4组,分析各组血清和腹腔液中CA125浓度与EM诊断的相关性。结果:血清CA125水平<10U/ml和≥16U/ml时,EM的诊断符合率分别为9.09%和89.55%,两组比较有显著差异(P<0.01)。腹腔液<800U/ml和≥800U/ml的EM诊断符合率分别为19.23%和94.80%,两组比较有显著差异(P<0.01)。血清CA125≥10U/ml结合腹腔液CA125≥800U/ml的诊断符合率为93.42%。结论:血清CA125≥10U/ml结合腹腔液CA125≥800U/ml对EM的诊断有重要参考价值。

Relationship of CA125 Level in Serum and in Abdominal Cavity Fluid and EM Diagnoses

Objective: To explore the relationship between the CA125 level of serum and abdominal cavity fluid and EM diagnosis.Methods: A total of 129 patients with suspected tubal infertileity,who underwent laparoscopy or hysteroscopy combined with laparoscopy,were collected.Serum and abdominal cavity fluid were collected before and during surgery,respectively,and CA125 level was measured then.The serum was divided into four groups according to the CA125 value: < 10,10-15,16-34 and ≥ 35 U/ml.Results: The coincident rate of EM diagnosis was 89.55% when the serum CA125 level was ≥ 16 U/ml.They were significantly higher than in CA125 < 10 U/ml group(9.09%)(P < 0.001).When the CA125 levels of abdominal cavity fluid were < 800 and ≥ 800 U/ml,the coincident rates were 19.23% and 94.80%,there was significant difference between them(P < 0.001).However,coincident rate was 93.42% when the serum CA125 levels were ≥ 10 IU/ml binding with ≥ 800 IU/ml of abdominal cavity fluid.Conclusion: Serum CA125 ≥ 10 U/ml binding with CA125 ≥ 800 U/ml of abdominal cavity fluid has important referenced value for EM diagnosis.