| TAC方案在乳腺癌新辅助化疗中的临床疗效观察 |
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| 引用本文： | 李怡,吴涛,尹国武,杨华光,杨艳红. TAC方案在乳腺癌新辅助化疗中的临床疗效观察[J]. 陕西肿瘤医学, 2010, 18(3): 499-500 |
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| 作者姓名： | 李怡 吴涛 尹国武 杨华光 杨艳红 |
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| 作者单位： | [1]第四军医大学唐都医院妇产科,陕西西安710038 [2]第四军医大学唐都医院普通外科,陕西西安710038 |
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| 摘 要： | 目的：探讨TAC（多西他赛＋阿霉索＋环磷酰胺）方案在乳腺癌新辅助化疗中的临床疗效。方法：35例Ⅱb-Ⅲa乳腺癌患者术前应用TAC方案进行2—4周期新辅助化疗，观察其有效率，并中位随访2年观察无病生存率及总生存率。结果：新辅助化疗后临床完全缓解（CR）8例，部分缓解（PR）20例，稳定（SD）3例，总有效率88．57％。其2年无病生存率与对照组有显著差异（P〈0．05），总生存率两组无差别（P〉0．05）。结论：应用TAC方案行新辅助化疗可有效提高乳腺癌患者临床缓解率，延长患者无病生存期。
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| 关 键 词： | 乳腺癌 TAC 新辅助化疗 |
Clinical effect of neoadjuvant chemotherapy with TAC regimen in breast cancer |
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| Affiliation: | LI Yi , WU Tao, YIN Guo - wu , YANG Hua - guang , YANG Yan - hong( 1 Department of Gynecology, 2 Department of General Surgery, Tangdu Hospital, the Fourth Military Medical University, Xi＇an 710038, China) |
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| Abstract: | Objective： To observe the clinical effect of neoadjuvant chemotherapy with TAC regimen in treatment of breast cancer. Methods ：Thirty five patients with clinical stage Ⅱ b- Ⅲ a breast cancer received neoadjuvant chemo- therapy with TAC regimen 2 to 4 cycles before operation. Disease - free survival rate （DFS） and overall survival rate （OS） were observed and compared during meazl 2 years follw -up. Results：Among 35 patients after neoadjuvant chemotherapy,8 were complete remission （CR） ,20 were partial remission （PR） ,and 3 were steady （SD）. The total effective rate was 88.57%. There was significanl difference of DFS between two groups （ P 〈 0.05 ）, but no difference in OS （P 〉 0.05 ）. Conclusion： Neoadjuvant chemotherapy using TAC regimen can improve clinical remission rate, and prolong DFS in breast cancer patients. |
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| Keywords: | breast cancer TAC neoadjuvant chemotherapy |
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