| 含原诱导缓解方案与多种不同方案强化治疗急性髓细胞白血病的疗效观察 |
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| 引用本文： | 殷献录,李静,姚伟,王景,罗瑞.含原诱导缓解方案与多种不同方案强化治疗急性髓细胞白血病的疗效观察[J].东南大学学报(医学版),2009,28(3):232-234. |
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| 作者姓名： | 殷献录 李静 姚伟 王景 罗瑞 |
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| 作者单位： | 安徽省蚌埠市第三人民医院,血液科,安徽,蚌埠,233000 |
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| 摘 要： | 目的: 探讨急性髓系白血病(AML)诱导缓解后的适宜强化治疗方案.方法: 37例AML患者随机分成原方案组和多种方案组,除复发者外,均强化治疗1～2年.原方案组采用原诱导缓解方案(DA或MA)、原诱导缓解方案联合依托泊苷或替尼泊苷或高三尖杉酯碱、原诱导缓解方案中的阿糖胞苷由常规剂量改为中或大剂量等方案进行交替化疗;多种方案组采用中或大剂量阿糖胞苷、HA、HAE、DA、DAE、MA、MAE、AA等方案交替应用,其中原诱导缓解方案应用2～3个疗程.结果: 原方案组和多种方案组患者 1年无病生存(DFS)率分别为76.5%和70%(P＞0.05),3年DFS率分别为46.7%和12.5%(P＜0.05).结论: 采用含诱导缓解方案的方法反复强化治疗AML,远期疗效优于多种不同方案交替治疗的方案.
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| 关 键 词： | 白血病 髓样 急性 药物疗法 强化治疗 无病生存 |
Induction regimen vs the multi-regimen consolidation chemotherapy in 37 patients with acute myeloid leukemia:a curative effects study |
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| YIN Xian-lu,LI Jing,YAO Wei,WANG Jing,LUO Rui.Induction regimen vs the multi-regimen consolidation chemotherapy in 37 patients with acute myeloid leukemia:a curative effects study[J].Journal of Southeast Univ: Medical Sci Ed,2009,28(3):232-234. |
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| Authors: | YIN Xian-lu LI Jing YAO Wei WANG Jing LUO Rui |
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| Institution: | Department of Hematology;Bengbu Third People's Hospital;Bengbu 233000;China |
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| Abstract: | Objective To explore the suitable consolidation therapy strategy of the acute myelogenous leukemia(AML) after complete cytomorphological remission(CR).Method Patients in complete remission were randomized for two cycles of consolidation therapy: the induction regimen group and the multi-regimen group.The former included the original induction regimen,the original induction regimen plus etoposide,teniposide or homoharringtonine.The routine dosage of cytarabine in the original induction regimen was changed in... |
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| Keywords: | leukemia myeloid acute pharmacotherapy intensification therapy disease-free survival |
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