灯笼草镇痛作用及其机理的研究

目的：观察灯笼草的镇痛作用。方法：采用扭体法、电刺激鼠尾－嘶叫法、钾离子透入法和辐射热－缩腿法等行为学指标以及丘脑束旁核神经元对伤害性刺激的放电反应的电生理指标。结果：灯笼草能剂量依赖地提高大鼠电刺激鼠尾－嘶叫法的痛阈，剂量依赖地抑制醋酸引起的小鼠扭体反应，对炎症性痛敏及神经源性痛敏灯笼草也有镇痛作用，灯笼草还能明显抑制丘脑束旁核神经元对伤害性刺激的放电反应。纳洛酮能翻转灯笼草的镇痛作用,反复给予灯笼草能产生耐受，但与吗啡镇痛之间不存在交叉耐受。结论：灯笼草具有镇痛作用，其镇痛作用可能涉及中枢阿片受体。

Experimental Study on theAnalgesic Effect and Its Mechanism of Physalis peruviana L.

Objective: The experiment was performed to study the analgesic effect of Physalis peruviana L. (PPL.) Methods: The behavioral algesic measurements and the electrophysiological method were used to record extracellularly the nociceptive response of thalamic parafascicular neurons. Results: 1) PPL could dose-dependently raise the pain threshold in tail stimulation-vocalization test in rats and inhibit the writhing reaction induced by acetic acid in mice. PPL could decrease the hyperalgesia in adjuvant arthritis as well was in neuropathic pain in rats. 2) PPL could inhibit the nociceptive response of thalamic parafascicular neurons in rats evoked by sciatic nerve stimulation. 3) The analgesic effect of PPL could be reversed by naloxone; tolerance could develop after repeated administrations of PPL, but no cross-tolerance was observed with morphine analgesia. Conclusion: PPL has a dose-dependent analgesic effect and its analgesic effect might be mediated by central opioid receptor.