Pancreatic surgery for tumors in children and adolescents |
| |
Authors: | Maria G Sacco Casamassima Colin D Gause Seth D Goldstein Fizan Abdullah Avner Meoded Jeffrey R Lukish Christopher L Wolfgang John Cameron David J Hackam Ralph H Hruban Paul M Colombani |
| |
Institution: | 1.Division of Pediatric Surgery,The Johns Hopkins School of Medicine,Baltimore,USA;2.Division of Pediatric Surgery, Department of Surgery,Ann & Robert H. Lurie Children’s Hospital of Chicago,Chicago,USA;3.Division of Pediatric Radiology, The Russell H. Morgan Department of Radiology and Radiological Science,Johns Hopkins University,Baltimore,USA;4.Department of Surgery,The Sol Goldman Pancreatic Research Center, The Johns Hopkins School of Medicine,Baltimore,USA;5.Department of Pathology, The Sol Goldman Pancreatic Research Center,The Johns Hopkins University School of Medicine,Baltimore,USA;6.Department of Surgery,Johns Hopkins All Children’s Hospital,Saint Petersburg,USA |
| |
Abstract: | PurposePancreatic neoplasms are uncommon in children. This study sought to analyze the clinical and pathological features of surgically resected pancreatic tumors in children and discuss management strategies.MethodsWe conducted a retrospective review of patients ≤21 years with pancreatic neoplasms who underwent surgery at a single institution between 1995 and 2015.ResultsNineteen patients were identified with a median age at operation of 16.6 years (IQR 13.5–18.9). The most common histology was solid pseudopapillary neoplasm (SPN) (n = 13), followed by pancreatic neuroendocrine tumor (n = 3), serous cystadenoma (n = 2) and pancreatoblastoma (n = 1). Operative procedures included formal pancreatectomy (n = 17), enucleation (n = 1) and central pancreatectomy (n = 1). SPNs were noninvasive in all but one case with perineural, vascular and lymph node involvement. Seventeen patients (89.5 %) are currently alive and disease free at a median follow-up of 5.7 (IQR 3.7–10.9) years. Two patients died: one with metastatic insulinoma and another with SPN who developed peritoneal carcinomatosis secondary to a concurrent rectal adenocarcinoma.ConclusionsPediatric pancreatic tumors are a heterogeneous group of neoplastic lesions for which surgery can be curative. SPN is the most common histology, is characterized by low malignant potential and in selected cases can be safely and effectively treated with a tissue-sparing resection and minimally invasive approach. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|