Perinatal features of congenital cystic lung diseases: results of a nationwide multicentric study in Japan |
| |
Authors: | Japanese Study Group of Pediatric Chest Surgery Tatsuo Kuroda Eiji Nishijima Kosaku Maeda Yasusih Fuchimoto Seiichi Hirobe Yuko Tazuke Toshihiko Watanabe Noriaki Usui |
| |
Affiliation: | 1.Department of Pediatric Surgery, Keio University,School of Medicine,Tokyo,Japan;2.Department of Pediatric Surgery,Takatsuki Hospital,Osaka,Japan;3.Department of Pediatric Surgery,Jichi Medical College,Shimotsuke,Japan;4.Department of Surgery,National Center for Child Health and Development,Tokyo,Japan;5.Department of Surgery,Tokyo Metropolitan Children’s Medical Center,Tokyo,Japan;6.Department of Pediatric Surgery,Osaka Medical Center and Research Institute for Maternal and Child Health,Osaka,Japan;7.Department of Pediatric Surgery,Osaka University,Osaka,Japan |
| |
Abstract: | PurposeThe current study aimed to assess the perinatal risk and clinical features of congenital cystic lung diseases (CCLD).Materials and methodsOf the 874 CCLD patients identified in a nationwide survey, 428 patients born between 1992 and 2012 and treated at 10 high-volume centers, were retrospectively reviewed.ResultsFetal hydrops was visualized using MRI in 9.2 % of the patients. Prenatal interventions were described for 221 of the 428 patients, including the maternal administration of steroid and pleuro-amniotic shunting. Postnatally, a right-to-left shunt flow through a persistent ductus arteriosus was observed in 7.8 % of the patients. The fetal lung lesion volume ratio (LVR) was significantly higher among these symptomatic patients (2.04 ± 1.71 vs. 0.98 ± 0.50, P < 0.00071), and decreased to a greater degree in non-CCAM patients compared with CCAM patients during the late gestational period (from 1.37 ± 1.28 to 1.14 ± 0.84 in CCAM and from 1.08 ± 0.47 to 0.46 ± 0.64 in non-CCAM).ConclusionsAn estimated 8–9 % of prenatally diagnosed patients carry the highest risk of perinatal respiratory distress. Fetal LVR remaining at a high level during the late gestational period seems to predict a high risk. |
| |
Keywords: | |
本文献已被 SpringerLink 等数据库收录! |
|