绝经前后妇女骨代谢生化指标与骨超声声速的关系

目的 观察绝经前后不同年龄妇女的骨超声声速和骨代谢生化指标的变化情况及相互关系。方法 共197例绝经前后妇女，其中89例为绝经前组，接年龄每隔10年分组，88例为绝经后组。用ELISA法测定各个骨形成与骨吸收指标，同时B超亩骨密度仪测定骨超声声速情况。结果 绝经前骨超声声速无明显改变，绝经后骨超声声速明显下降，骨超声声速在绝经后与年龄及绝经年限呈负相关。骨超声声速与骨吸收指标呈负相关。骨吸收指标Pyd不但在绝经后明显上升，且在绝经前的第3组妇女中已较前有明显升高。结论 骨代谢生化指标的改变先于骨超声声速的改变，骨量和骨代谢指标测定相结合，可能更有助于预测将来发生骨折的危险程度。

Relationship between bone biochemical markers and speed of sound in pre-and post-menopausal women

Objective To study the relationship between bone markers and bone speed of sound (SOS) in women of different ages. Methods 197 women were divided into two groups, 89 premenopausal women and 88 postmenopausal women.All bone formation and resorption markers were measured by enzyme linked immunosorbent assay(ELISA).SOS were measured by ultrasound. Results SOS was lower in postmenopausal women but not in premenopausal women.SOS decreased with age in the postmenopausal women and was negatively related to years since menopause.SOS was also negatively related to bone resorption markers. Pyridinoline (Pyd)in the third subgroup of premenopausal subjects already significantly increased compared with bone formation markers. Conclusions The change in SOS lags behind the change in bone biochemical markers.Measuring SOS and bone biochemical markers at the same time will be useful for calculating the risk of fracture.