Convulsive properties of lindane, lindane metabolites, and the lindane isomer alpha-hexachlorocyclohexane: effects on the convulsive threshold for pentylenetetrazol and the brain content of gamma-aminobutyric acid (GABA) in the mouse. |
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Authors: | Lars Hulth Lena Höglund Åke Bergman Lennart Möller |
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Affiliation: | 1. Institute of Zoophysiology, University of Uppsala, P.O. Box 560, S-751 22 Uppsala, Sweden;2. Environmental Toxicology Unit, Wallenberg Laboratory, University of Stockholm, S-106 91 Stockholm, Sweden |
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Abstract: | The threshold for pentylenetetrazol-induced convulsions in the mouse is affected by lindane in two opposite ways. Following the administration of a single dose of lindane, the threshold first decreases and then, after 2 days, increases above the normal level. None of the tested metabolites of lindane altered the convulsive threshold. When lindane elevates the convulsive threshold it also elevates the content of γ-aminobutyric acid (GABA) in the brain. The lindane isomer α-hexachlorocyclohexane elevates both convulsive threshold and the GABA content. The smallest single oral dose of lindane lowering the convulsive threshold for pentylenetetrazol in the mouse, 3 hr after administration, corresponds to a lindane concentration of 56 ppb in whole blood. |
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