国产芦氟沙星人体药代动力学与生物利用度研究

报道９ 名男性健康志愿者随机自身交叉对照口服芦氟沙星国产片剂、国产胶囊和进口片剂各２００ｍ ｇ 后的药代动力学与相对生物利用度研究结果。采用反相高效液相色谱法测定血、尿药物浓度，该药体内过程符合二室开放模型。国产片剂、胶囊与进口片剂分别在３．３１±１．９１、２．３２±１．４２和２．５２±２．１８ｈ 达血药峰浓度，其均值分别为２．２５±０．４７、２．２２±０．５９ 和２．４５±０．７３ｍ ｇ／Ｌ；药时曲线下面积（ＡＵＣ０～ｉｎｆ）分别为１１７．４８±１２．０８、１２０．９３±２１．８０ 和１１７．２１±１７．６１ｈ·ｍ ｇ／Ｌ；消除半衰期分别为４８．７±９．２、５７．９±１７．２ 和４７．５±１４．０ｈ。服用上述３ 种制剂后１０８ｈ 内尿中原型药物排出率分别占给药量的（５２．９±５．１）％ 、（７０．９±９．５）％ 和（５７．８±１０．１）％ 。３ 种制剂的药代动力学参数相互比较均无显著性差异；相对生物利用度研究结果表明，３种芦氟沙星制剂具有生物等效性。

Effect of oral aluminium hydroxide on the pharmacokinetics of intravenous norfloxacin in rabbits

The effect of oral aluminium hydroxide suspension on the pharmacokinetics of intravenous norfloxacin injection in rabbits was studied. Eight normal rabbits received intravenous norfloxacin injection with and without oral aluminium hydroxide suspension in a randomized crossover design separated by 7 days. The concentration of norfloxacin in serum was determinted by UV spectrophotometry. The result showed that with concomitant administration of aluminium hydroxide, the pharmacokinetic parameters of norfloxacin had no significantly different with the single administration group. We conclude that intravenous administration norfloxacin can be concomitantly administered with oral aluminium contained preparation.