酒大黄的镇痛抗炎作用

目的:观察酒大黄的镇痛抗炎作用.方法:采用小鼠热板法和小鼠扭体法观察酒大黄(2,1,0.5 g·kg-1·d-1,ig连续7d)的镇痛作用,采用小鼠耳肿胀法和小鼠棉球肉芽肿法观察酒大黄(2,1,0.5 g·kg-1ig,连续7d)的抗炎作用.结果:酒大黄能提高热板法疼痛模型小鼠痛阈,抑制醋酸致小鼠扭体反应,并能抑制二甲苯致小鼠耳肿胀和皮下植入棉球所致的小鼠肉芽肿生成(均P＜0.05).结论:酒大黄有良好的镇痛抗炎作用.

Analgesic and Anti-inflammatory Effect of Prepared Rhei Radix et Rhizoma with Wine

Objective:To investigate the analgesic and anti-inflammatory effect of prepared Rhei Radix et Rhizoma with wine. Method: The analgesic effects of prepared Rhei Radix et Rhizoma with wine were observed by hot-plate in mice and acetic acid writhing assay(2,1,0.5 g·kg^-1,ig,for 7 d).The anti-inflammatory effect were observed by evaluating xylene-induced ear edema in mice and cotton ball-induced granuloma in mice(2,1,0.5 g·kg^-1,ig,for 7 d). Result: Prepared Rhei Radix et Rhizoma with wine could prolong the latent time of reaction on hot-plate in mice, and reduce the wristle reaction times in mice.It could inhibit the ear edema caused by xylene in mice and the granuloma hyperplasia caused by cotton ball (all P<0.05). Conclusion: Prepared Rhei Radix et Rhizoma with wine has anti-inflammatory and analgesic effect.