| 非小细胞肺癌ERCC1、TS的表达及临床意义 |
| |
| 引用本文： | 宋子琰,王红兵.非小细胞肺癌ERCC1、TS的表达及临床意义[J].白求恩军医学院学报,2012,10(6):451-453. |
| |
| 作者姓名： | 宋子琰 王红兵 |
| |
| 作者单位： | 宋子琰 (江苏省连云港市徐州医学院附属连云港市一院化疗科,222000) ； 王红兵 (江苏省徐州医学院附属徐州二院化疗科,221002) |
| |
| 摘 要： | 目的研究非小细胞肺癌(non-small cell lung cancer,NSCLC)组织中核苷酸切除修复交叉互补基因1(ERCC1)、胸苷酸合酶(TS)的表达及临床意义。方法采用免疫组化法测定51例患者NSCLC组织中的ERCC1、TS的表达情况。结果非小细胞肺癌组织中ERCC1、TS的阳性表达率分别为49.0%和60.8%,与患者的年龄、性别、组织学类型、临床分期、淋巴结有无转移均无明显相关性(P0.05);TS与分化程度有关(P0.05)。ERCC1、TS表达呈正相关(P0.01)。结论 NSCLC组织中ERCC1、TS高表达,有望成为NSCLC个体化治疗有预测价值的分子标志物。
|
| 关 键 词： | 非小细胞肺癌 核苷酸切除修复交叉互补基因 胸苷酸合酶 |
Expression and clinical significance of ERCC1、TS protein in non-small cell lung cancer |
| |
| SONG Ziyan,WANG Hongbing.Expression and clinical significance of ERCC1、TS protein in non-small cell lung cancer[J].Journal of Bethune Military Medical College,2012,10(6):451-453. |
| |
| Authors: | SONG Ziyan WANG Hongbing |
| |
| Institution: | .Department of Oncology,the Affiliated Hospital of Xuzhou Medical College,Lianyungang,Jiangsu 222000,China |
| |
| Abstract: | Objective To study the expression of ERCC1、TS protein in non-small cell lung cancer,and explore its clinical significance.Methods The expression of ERCC1 and TS protein in 51 patients with NSCLC was detected by immunohistochemical methods.Results The positive expression of ERCC1 and TS protein in 51 patients with NSCLC was 49.0% and 60.8% respectively which has no significant correlation with the patients＇age,gender,histological types,clinical stages and lymph node metastasis status（P0.05）.The positive expression of TS protein was related to differentiation degree（P0.05）.The expression of ERCC1 and TS was positively correlated（P0.01）.Conclusion The higher expression levels of ERCC1 and TS in NSCLC may become predictive biomarkers in individualized treatment of NSCLC. |
| |
| Keywords: | Non-small cell lung cancer ERCC1 TS |
| 本文献已被 CNKI 维普 等数据库收录！ |
