龙脷平喘汤(肺鼻同治)治疗热证小儿哮喘

目的:探讨依据“肺鼻同治”创立的龙脷平喘汤治疗急性发作期热证小儿哮喘的临床疗效.方法:采用随机区组设计、平行对照的研究方法,将60例患儿分为治疗组(龙脷平喘汤组)和对照组(氨茶碱加舒利迭),每组30例.治疗组平均年龄(7.99 ±2.52)岁；病情分级:轻度9例,中度21例；过敏性鼻炎23例.对照组平均年龄(8.02 ±2.44)岁；病情分级:轻度11例,中度19例；过敏性鼻炎21例.分别给予14 d治疗后,主要观察临床总疗效,过敏性鼻炎症状评分,外周血嗜酸性粒细胞(EOS)计数,最大呼气流量(PEF)、一秒钟用力呼气容积(FEV1).结果:治疗组临床总有效率93.3％,与对照组临床总有效率90％比较,无显著性差异.与治疗前比较,两组治疗后过敏性鼻炎症状评分均显著降低(P＜0.05),且治疗组临床总有效率(87％)与对照组(71.4％)比较差异有显著意义(P＜0.05).治疗后,两组EOS计数均明显降低(P＜0.05),但治疗组与对照组比较差异无统计学意义.治疗后,两组PEF,FEV1测得值与治疗前比较均显著升高(P＜0.01),但治疗组与对照组比较差异无统计学意义.结论:龙脷平喘汤治疗急性发作期热证小儿哮喘的临床疗效明显,具有抑制气道炎症,改善哮喘患儿过敏性鼻炎症状,缓解支气管平滑肌痉挛、降低气道阻力,改善肺的呼吸功能等作用.

Clinical Study of Longli Pinchuan Tang(Treating Lung and Nose Disease Simultaneously)Treating Heat Syndrome Infantile Asthma

Objective:To discuss the clinical effects that the Longli Pinchuan tang of the found base on treating lung and nose disease simultaneously treats heat syndrome infantile asthma in acute onset stage. Method : Sixty cases were divided into treatment group and control group at experimental design principle of randomized block and parallel controlled trial, each group had 30 cases. The average age of treatment group is(7.99±2.52), patient's condition grading: mild 9 cases, moderate 21 cases, 23 cases of allergic rhinitis. The average age of control group is (8.02±2.44), patient's condition grading: mild 11 cases, moderate 19cases, 21 cases of allergic rhinitis. 14 days after treatment, mainly observe and recorded allergic rhinitis symptom scores, counts of peripheral blood easinophilic(EOS), numerical values of peak espiratory flow(PEF),forced expiratory volume in 1 second(FEV₁). Result: Clinical total effective rate of treatment group is 93.3%, the difference comparing with control group is not statistically significant. Allergic rhinitis symptom scores are significantly lower comparing with before treatment between 2 groups(P<0.05),and clinical total effective rate (87%)of treatment group is statistically significant comparing with it of control group(P<0.05). In posttreatment, the counts of peripheral blood EOS were significantly lowe and numerical values of PEF,FEV₁. were significantly rise(P<0.05,P<0.01), but the comparison difference is not statistically significant between treatment group and control group. Conclusion : The clinical effects that the Longli Pinchuan tang treated heat syndrome infantile asthma in acute onset stage was obvious.It can inhibition airway inflammation, improve asthma children allergic rhinitis symptoms, ease bronchial smooth muscle spasm, reduce airway resistance, and improve lung respiratory function.