| 大鼠阻塞性睡眠呼吸暂停综合征动物模型的建立 |
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| 引用本文： | 柳忠禄,王岩,李延忠.大鼠阻塞性睡眠呼吸暂停综合征动物模型的建立[J].山东医大基础医学院学报,2009(2):31-33. |
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| 作者姓名： | 柳忠禄 王岩 李延忠 |
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| 作者单位： | 山东大学齐鲁医院耳鼻咽喉头颈外科、卫生部耳鼻喉科学重点实验室; |
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| 基金项目： | 山东省医药卫生科技发展计划(编号2005HZ032) |
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| 摘 要： | 目的建立一个稳定、可靠的阻塞性睡眠呼吸暂停综合征（OSAS）动物模型。方法将8只Wistar大鼠的双侧舌腭弓、咽腭弓及舌根处注射透明质酸钠,分别于注射前及注射后4周,以浅状态模拟睡眠状态,用多导睡眠仪监测动物的脑电、肌电及口鼻气流。结果①动物处于浅麻醉状态时,脑电和肌电活动与睡眠时相似;②注射前和注射后4周,动物在监测过程中均出现伴有胸腹反常运动的呼吸暂停,但是注射前后呼吸暂停指数（AI）及最长呼吸暂停时间之间差异有统计学意义（P〈0.05）。结论咽部注射透明质酸钠法所建立的大鼠阻塞性睡眠呼吸暂停综合征模型稳定、可靠,与人类OSAS相似,可应用于OSAS的发病机制、病理生理改变和并发症等方面的研究。
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| 关 键 词： | 睡眠呼吸暂停 阻塞性 大鼠 Wistar 动物模型 |
Animal model of obstructive sleep apnea syndrome in rats |
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| LIU Zhong-lu,WANG Yan,LI Yan-zhong.Animal model of obstructive sleep apnea syndrome in rats[J].Journal of Preclinical Medicine College of Shandong Medical University,2009(2):31-33. |
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| Authors: | LIU Zhong-lu WANG Yan LI Yan-zhong |
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| Institution: | Department of Otorhinolaryngology & Head and Neck Surgery;Qilu Hospital of Shandong University;Key Laboratory of Otorhinolaryngology of Health Ministry;Jinan 250012;China |
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| Abstract: | Objective To build up a steady and credible animal model of obstructive sleep apnea syndrome(OSAS).Methods Sodium Hyaluronate was injected into the palatoglossal arch,palatopharyngeal arch and root of the tongue of eight Wistar rats.An electroencephalogram,electromyogram and oro-nasal airflow were recorded by PSG before and 4 weeks after injection when rats were under light anesthesia,which was expected to be similar to the sleep state.Results When the animals were under light anesthesia,the electroencephal... |
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| Keywords: | Sleep apnea obstructive Rats Wistar Animal models |
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