肾炎康复片对早期糖尿病肾病患者肾小球、肾小管标志性蛋白/酶的影响

目的 研究肾炎康复片对早期糖尿病肾病患者肾小球、肾小管标志性蛋白/酶的影响.方法 早期糖尿病肾病患者50例,随机分为治疗组和对照组,各25例,两组均采用糖尿病适宜的饮食、运动方案,在控制血糖、血脂等基础上,治疗组给予肾炎康复片5片,每日3次口服,3个月为1个疗程,对照组给予安慰剂.观察治疗前、后两组血肌酐（Scr）、尿素氮（BUN）、糖化血红蛋白A1c（HbA1c）、超敏C反应蛋白（hs-CRP）及24 h尿总蛋白、白蛋白、N-乙酰-β-氨基葡萄糖苷酶（NAG）、β2-微球蛋白（β2-MG）、视黄醇结合蛋白（RBP）的变化.结果 治疗组治疗后血hs-CRP由（4.52±2.01） mg/L降至（3.09±0.85） mg/L,尿NAG由（19.28±7.04） U/L降至（13.70±6.61） U/L,β2-MG由（0.56±0.13） mg/L降至（0.35±0.20） mg/L,RBP由（2.83±1.21） mg/L降至（1.40 ± 0.69） mg/L,较治疗前明显下降,差异有统计学意义（t值分别为2.808,4.523,3.418,3.977,P ＜0.05）,而对照组治疗前、后无明显变化（P均＞0.05）.治疗组治疗后24h尿总蛋白由（0.40±0.12） g/24h降至（0.28±0.15） g/24h,ALB由（105.91±41.50） mg/24h降至（65.05±42.52） mg/24 h,治疗前、后差异有统计学意义（t值分别为5.726,4.234,P均＜0.05）,对照组24 h尿总蛋白和ALB也均下降（t值分别为2.325,1.701,P均＜0.05）,但治疗组下降更明显（P＜0.05）.结论 肾炎康复片可减少肾小球性尿白蛋白排泄,减轻肾小管损伤.

Effects of Shenyankangfu tablet on glomerular and tubular iconic protein/enzyme in patients with early diabetic nephropathy

Objective To investigate the effects of Shenyankangfu tablet on glomerular and tubular iconic protein/enzyme in patients with early diabetic nephropathy.Methods Fifty patients with early diabetic nephropathy were randomly divided into treatment group （n=25） and control group （n=25）.Both groups adopted the diabetic diet,exercise programs.Patients in the treatment group were treated with Shenyankangfu tablet on the base of their blood glucose and lipids control,while patients in the control group received placebo.The changes of serum creatinine （Scr）,blood urea nitrogen （BUN）,glycated hemoglobulinA 1 c （HbA 1 c）,hs-C reactive protein （CRP）,and 24-hour urine total protein,albumin,N-acetyl-β-amino-glucosidase （NAG）,β2-microglobulin （β2-MG）,retinol binding protein （RBP） before and after the treatment were tested.Results The bloodhs-CRP,urinary NAG dropped,β2-MG,RBP decreased significantly in treatment group （all P〈0.05）,but did not change in control group （all P 〉0.05）.The level of blood hs-CRP decreased from （4.52 ± 2.01） mg/L to （3.09 ± 0.85） mg/L,urinary NAG dropped from （19.28 ± 7.04） U/L to （13.70 ± 6.61） U/L,β2-MG reduced from （0.56 ± 0.13）mg/L to （0.35 ± 0.20） mg/L,RBP decreased from （2.83 ± 1.21） mg/L to （1.40 ± 0.69） mg/L respectively （t value were 2.808,4.523,3.418 and 3.977,all P 〈0.05） in treatment group.After treatment,24-hour urinary total protein and albumin decreased in both groups （all P〈0.05）,but reduced more in treatment group （P〈0.05）.The level of 24-hour urinary total protein decreased from （0.40 ± 0.12） g/24 h to（0.28 ± 0.15） g/24 h,and urinary albumin decreased from （105.91 ± 41.50） mg/24 h to （65.05 ± 42.52） mg/24 h,respectively （t value were 5.726,4.234,all P〈0.05） in treatment group.Conclusion Shenyankangfu tablet can reduce glomerular urinary protein excretion and tubular injury.