国产苯溴马龙与痛风利仙治疗高尿酸血症的随机对照研究

目的：评价国产苯溴马龙胶囊治疗高尿酸血症的有效性与安全性。方法：采用非盲法随机对照试验，将纳入的40例痛风高尿酸血症病人随机分入国产苯溴马龙组与痛风利仙（进口苯溴马龙）组，每组20例。两组药物均为50mg／日,晨服一次，疗程两周。结果：两组病例治后血尿酸值均明显下降，治后一周下降更明显，与24小时尿尿酸排泄量增高程度基本一致。治后两组的显效率和总有效率分别为65．00％和95．00％与80．00％和85．00，差异无统计学意义（p=0．653、0．218)。两组不良反应发生率分别为10．00％和0％。不良反应轻微，未见肝、肾功能损害发生。结论：国产苯溴马龙胶囊是一强力排尿酸药，使用方便安全

A Randomized Controlled Clinical Study of Domestic Benzbromarone and Narcaricin on Hyperuricaemia

Objective:To evaluate the efficacy and safety of domestic Benzbromarone in the treatment of hyperuricaemia.Methods:A randomized controlled clinical study was conducted.40 patients entered this study and 20 cases in each group.Narcaricin mite was used as a control drug.The two medicines both were given 50mg once daily for 2 weeks.Results:Plasmatic urate reduced obviously after treatment,especially after one-week treatment,and accorded with the increase of urate excreted within 24 hours.The excellent efficacy rates and the effective rates were 65 00% and 95 00% in test group and 80 00% and 85 00% in controlled group respectively.There were no significant statistical differences between the two groups(p=0 653,0 218).The adverse drug reaction rates of the two group' were 10 00% and 0% respectively.The reactions were mild,and no damage to the function of liver and kidney was observed.Conlusion:As same as Narcaricin mite,the domestic Benzbromarone is an effective and safe uricosuric medicine and is convenient to use.