Angiotensinogen gene variations and LV outflow obstruction in hypertrophic cardiomyopathy |
| |
| Authors: | S Wang J Wang Y Zou J Wang H Wang R Hui MD PhD |
| |
| Institution: | 1. The First Geriatric Cardiology Department, Chinese Peoples’ Liberation Army General Hospital, 167 Beilishi Road, 100037, Beijing, China
2. Sino-German Laboratory for Molecular Medicine, Key Laboratory for Clinical Cardiovascular Genetics of the Ministry of Education, 167 Beilishi Road, 100037, Beijing, China
|
| |
| Abstract: | Background Variations of angiotensinogen (AGT) gene have been associated with cardiac hypertrophy. We hypothesized that AGT gene polymorphism may play a modifier role in the diversity of left ventricular outflow obstruction. Methods The polymorphisms of the AGT gene were genotyped in 225 patients with hypertrophic cardiomyopathy (HCM) and 243 age-and sex-matched healthy controls. The effect of the A and G alleles on the expression of the reporter gene were evaluated in vitro using dual-luciferase reporter assays. Results Our results showed that the frequency of the A allele was higher in patients than in controls (50.2?% vs. 35.8?%, p?<?0.05). Patients carrying the AA and AG genotypes had a higher proportion of left ventricular outflow obstruction (30.1?% vs. 17.0?%, p?<?0.05) and heart failure (NYHA functional class III?~?IV, 35.4?% vs. 18.8?%, p?<?0.05) than those carrying the GG genotype had. After adjusted for age, sex, the thickness of the interventricular septum, family history of HCM, and sudden death, the A allele conferred a 2.4-fold risk for left ventricular outflow obstruction than the GG genotype did (adjusted OR?=?2.4, 95?%CI 1.2–4.8). The G allele suppressed the expression of the reporter gene significantly compared with the A allele (p?<?0.05). Conclusion AGT gene variations may be genetic modifiers for the development of HCM. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
