| 硒和维生素E对大鼠心肌单胺类物质和单胺氧化酶的影响 |
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| 引用本文： | 金毅 李保玉. 硒和维生素E对大鼠心肌单胺类物质和单胺氧化酶的影响[J]. 中国地方病防治杂志, 1997, 12(2): 71-72 |
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| 作者姓名： | 金毅 李保玉 |
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| 作者单位： | 白求恩医科大学应用基础医学研究所(金毅，李保玉，李广生，孙波)，白求恩医科大学应用基础医学研究所(张秀云) |
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| 摘 要： | 本文观察了硒（Ｓｅ）和维生素Ｅ（ＶＥ）对大鼠心肌去甲肾上腺素（ＮＥ）、多巴胺（ＤＡ）、５羟色胺（５－ＨＴ）含量和单胺氧化酶Ａ（ＭＡＯ－Ａ）、单胺氧化酶Ｂ（ＭＡＯ－Ｂ）活性的影响，发现经低Ｓｅ、低ＶＥ饲料喂养１０周，并且处死前经２次冰浴刺激的大鼠心肌ＮＥ含量明显增高，ＭＡＯ－Ａ活性降低，ＭＡＯ－Ｂ活性增加，通过补充饲料中Ｓｅ和ＶＥ，对上述指标有不同程度的改善，并以联合补充Ｓｅ和ＶＥ效果最佳。本研究结
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| 关 键 词： | 硒 维生素E 单胺类物质 单胺氧化酶 克山病 |
EFFECT OF SELENIUM AND VITAMIN E ON MONO AMINES AND MONOAMINE OXIDASE |
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| Jin YiInstitute of Preclinical Science,Norman Bethune University of Medical Sciences. EFFECT OF SELENIUM AND VITAMIN E ON MONO AMINES AND MONOAMINE OXIDASE[J]. Chinese Journal of Control of Endemic Disenaces, 1997, 12(2): 71-72 |
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| Authors: | Jin YiInstitute of Preclinical Science Norman Bethune University of Medical Sciences |
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| Abstract: | The paper discussed the effect of selenium and vitamin E on the content of Norepinephrine (NE),Dopamine(DA) , 5-Hydroxytryptamine(5-HT)and activity of monoamine oxidase(MAO) in myocardium of rats fed on diet of selenium and vitamin E deficiency for 10 weeks ,the rats had been swum in ice water 5 minutes for two times before killed. The results show that the content of NE,DA,5-HT were increased, the activity of MAO-A were decreased and the activity of MAO-B were enhanced in the rats myocardium,on the contrary,in rats in the diet of selenium and vitamin E supplement ,the content of NE ,DA ,5-HT and activity of MAO-A ,MAO-B were changed. The results suggested that selenium and vitamin E supplement in the rats fed on grain of low-selenium and low-vitamin E would conduced to improve metabolic disorder of monoamine in myocardium and to research the pathologic mechanism of Keshan disease. |
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| Keywords: | Selenium V-itamin E Monoamines Monoamine oxidase |
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