Vehicle Composition Influence on the Microneedle-Enhanced Transdermal Flux of Naltrexone Hydrochloride |
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| Authors: | Mikolaj Milewski Audra L Stinchcomb |
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| Institution: | (1) Department of Pharmaceutical Sciences, College of Pharmacy, University of Kentucky, 459 Wethington Bldg., 900 South Limestone Street, Lexington, Kentucky 40536-0082, USA; |
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| Abstract: | Purpose Transdermal delivery of drugs is often limited by formidable barrier properties of stratum corneum (SC). Microneedles (MN)
enable creation of transient microchannels in the SC and bypass this barrier. Many reports have focused on the great effectiveness
of MN in improving percutaneous flux values of a variety of drugs over a large molecular size spectrum. The objective of the
present study is to evaluate the influence of formulation on MN-enhanced transdermal transport of naltrexone hydrochloride
(NTX HCl). |
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