High Loading of Gentamicin in Bioadhesive PVM/MA Nanostructured Microparticles Using Compressed Carbon-Dioxide |
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| Authors: | Elisa Elizondo Santiago Sala Edurne Imbuluzqueta David González María J Blanco-Prieto Carlos Gamazo Nora Ventosa Jaume Veciana |
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| Institution: | 1.Department of Molecular Nanoscience and Organic Materials,Institut de Ciència de Materials de Barcelona (ICMAB-CSIC),Bellaterra,Spain;2.CIBER de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN),Bellaterra,Spain;3.Department of Pharmacy and Pharmaceutical Technology,University of Navarra,Pamplona,Spain;4.Department of Microbiology,University of Navarra,Pamplona,Spain |
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| Abstract: | Purpose To investigate, for the first time, the viability of compressed antisolvent methodologies for the preparation of drug-loaded
particles of the biodegradable and bioadhesive polymer poly (methyl vinyl ether-co-maleic anhydride) (PVM/MA), utilizing gentamicin
(Gm) as a model drug. |
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