| 3，5-二羟苯甘氨酸致痈模型的研究进展 |
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| 引用本文： | 刘建盛,陆钦池. 3，5-二羟苯甘氨酸致痈模型的研究进展[J]. 中国临床神经科学, 2009, 17(5): 544-547 |
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| 作者姓名： | 刘建盛 陆钦池 |
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| 作者单位： | 上海交通大学医学院附属仁济医院神经内科,200127 |
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| 摘 要： | 癫痫动物模型是研究癫痫发病机制和药物靶点的重要工具。3,5-二羟苯甘氨酸（DHPG）是近年来发现的一种新的化学致痫剂，在离体脑片及整体动物上均能诱导出癫痫样活动，本文对有关DHPG诱导癫痂动物模型的研究进展作一综述。
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| 关 键 词： | 代谢性谷氨酸受体 3,5-二羟苯甘氨酸 癫痼 动物模型 |
Progress in Animal Model for Epilepsy Induced by 3,5-dihydroxyphenylglycine |
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| LIU Jian-Sheng,LU Qin-Chi. Progress in Animal Model for Epilepsy Induced by 3,5-dihydroxyphenylglycine[J]. Chinese Journal of Clinical Neurosciences, 2009, 17(5): 544-547 |
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| Authors: | LIU Jian-Sheng LU Qin-Chi |
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| Affiliation: | ( Department of Neurology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200127, China) |
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| Abstract: | Animal model is a fundamental tool for identifying pathogenesis and pharmacological target involved in epilepsy. 3,5-dihydroxyphenylglycine（DHPG） is a novel convulsant found recently, which can induce epileptiform activity both in vitro and in vivo. The progress in the animal model induced by DHPG were reviewed. |
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| Keywords: | metabotropic glutamate receptor 3, 5-dihydroxyphenylglycine epilepsy animal model |
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