不同疗程三联药物治疗儿童幽门螺杆菌感染的疗效观察

目的：研究埃索美拉唑、克拉霉素、阿莫西林三联不同疗程治疗儿童幽门螺杆菌感染的疗效及差异性。方法：经13C-尿素呼吸试验（13C-UBT）证实为幽门螺杆菌感染的反复腹痛儿童105例，随机分为治疗A组60例，给予埃索美拉唑、克拉霉素、阿莫西林三联治疗，疗程1周；治疗B组45例，接受A组方案，但疗程2周，停药后4周门诊复诊并复查13C-UBT。结果：105例儿童腹痛均有不同程度缓解，缓解率100%；治疗A组幽门螺杆菌转阴55例，根除率91.7%，治疗B组幽门螺杆菌转阴42例，根除率93.3％。结论：埃索美拉唑、克拉霉素、阿莫西林三联治疗儿童幽门螺杆菌感染临床疗效好，幽门螺杆菌根除率高，毒副作用少见，安全性好；1周疗程与2周疗程在临床疗效与幽门螺杆菌根除率方面未见明显差异，1周疗程比2周疗程更为经济。［中国当代儿科杂志，2007，9（3）：205-206］

Different courses of esomeprazole-based triple therapy for Helicobactor pylori infection in children

Objective To study the efficacy of esomeprazole-based 1 week or 2 weeks triple therapy for Helicobactor pylori (H. pylori) infection in children. Methods One hundred and five children with H. pylori infection identified by 13C-UBT were randomly assigned into Group A (n=60) and Group B (n=45). The patients of the two groups were administered with 1 week or 2 weeks triple therapy consisting of esomeprazole, clarithromycin and amoxillin, respectively. They were followed up four weeks after drug withdrawal. Results Recurrent abdominal pain was relieved in all of patients. Fifty-five patients (91.7%) showed 13C-UBT negative in Group A and 42 (93.3%) presented negative in Group B. There was no significant difference in the eradication rate of H. pylori. Conclusions Esomeprazole-based triple therapy for H. pylori infection is effective in children. The efficacy of esomeprazole-based 1 week or 2 weeks triple therapy for this disorder does not appear to be different.