前列腺癌的组织结构与病理分类——附83例临床病理分析与PSA标记

本文对83例前列腺癌(Prostate carcinoma,PC)的临床病理资料作了回顾性分析并作了PSA标记。根据Dhom分类对本组PC进行了归类,发现常见癌66例(79.5％),少见癌14例(16.9％),不能归入Dhom分类的癌3例(3.6％)。常见癌中的单一结构癌41例(49.4％),混合结构癌25例(30.1％)。不同类型和不同分化的PC对PSA反应强度差异明显,其中高分化腺癌、筛状癌和类癌显强阳性;低分化腺癌、几乎全部混合结构癌及少见癌显阳性及/或弱阳性;未分化癌和小细胞癌显极弱阳性;鳞癌阴性。本文还对目前国内外常用的几组PC之病理分类进行了比较分析与讨论。

Pathological study and PSA marking of 83 cases of prostatic carcinoma

The clinical and pathological materials of 83 cases of prostatic carcinoma (PC) were reviewed retrospectively and the tissue specimens of PC were marked with prostate-specific antigen (PSA). According to the criteria of Dhom's classification of prostatic carcinoma. 66 cases out of the 83 (79. 5%) were of the common variety of PC, 14 cases (10. 9%) were of the rare variety and 3 cases (3. 6%) could not be classified with Dhom's method. Among the 66 cases of common prostatic carcinoma, 41 cases (49. 4%) exhibited a pathological structure of u-riiforrn pattern and 25 cases (30. 1%) of pluriform pattern. Well-differentiated adenocarcinoma, cribriform carcinoma and carcinoid of the prostate were strongly positive to PSA marking; poorly-differentiated adenocarcinoma and almost all the prostatic carcinomas of the rare variety and with the structure of pluriform pattern were positive or weakly positive; undifferentiated solid carcinoma and small cell carcinoma were very weakly positive; and squamous cell carcinoma was negative. In addition, other methods for the pathological classification of prostatic carcinoma used currently at home and abroad were compared and discussed.