Cardiac biopsy evidence for a cardiomyopathy associated with symptomatic mitral valve prolapse |
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Authors: | Jay W. Mason Francis H. Koch Margaret E. Billingham Roger A. Winkle |
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Affiliation: | From the Division of Cardiology, and the Department of Pathology, Stanford University School of Medicine, Stanford, California, USA |
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Abstract: | Right ventricular endomyocardial biopsy was performed in 14 patients with mitral valve prolapse to determine the existence of an associated cardiomyopathic process. All 14 patients had echocardiographic, angiographic or auscultatory evidence of mitral valve prolapse, and all were symptomatic. The group had a high incidence rate of conduction system abnormalities (50 percent) and arrhythmias (64 percent), but only one patient had a significant hemodynamic abnormality. Light microscopy revealed an increase in endocardial and interstitial fibrosis in eight patients (57 percent). Electron microscopy, performed in 11 patients, showed mitochondrial degenerative changes in all 11. Nuclear chromatin clumping, intracell edema and myocyte degeneration were frequently present. It is concluded that endomyocardial and myocardial abnormalities exist in some symptomatic patients with idiopathic mitral valve prolapse. |
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Keywords: | Address for reprints: Jay W. Mason MD Cardiology Division Stanford University School of Medicine Stanford California 94305. |
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