Bioavailability of salvianolic acid B and effect on blood viscosities after oral administration of salvianolic acids in beagle dogs |
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Authors: | Dong-Yan Gao Li-Mei Han Li-Hong Zhang Xiao-Ling Fang Jian-Xin Wang |
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Institution: | (1) Department of Pharmaceutics, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai, 201-203, PR China;(2) Laboratory of Receptor-based Biomedicine, School of Life Sciences and Technology, Tongji University, Shanghai, 200-092, PR China;(3) School of Pharmacy, Fudan Universiy, 826 Zhangheng Road, Shanghai, 201203, PR China |
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Abstract: | Salvianolic acid B (SalB) is an active component isolated from Chinese herbal medicine Salvia miltiorrhiza. The aim of this study was to investigate the extent of absolute oral bioavailability (F) of SalB in beagle dogs and the
effect on blood viscosity after intravenous and oral administration of Salvianolic acids (SAs). A gradient elution HPLC method
was developed and validated to determine the concentration of SalB and its three possible metabolites in plasma. After SAs
(180 mg/kg, p.o.; 9 mg/kg, i.v.) were given, the AUCs of SalB were 1680 ± 670 and 7840 ± 1140 ng/mL·h, respectively. The F
of SalB in dogs was calculated to be only 1.07 ± 0.43%. The blood viscosity was remarkably decreased after a single intravenous
injection of SAs (9 mg/kg). However, no significant change of blood viscosity was observed after a single oral administration
of SAs (180 mg/kg). The results suggested that the F of SalB was extremely low and single oral administrated SAs had no effect
on ameliorating blood viscosity in beagle dogs. |
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Keywords: | Salvianolic acids Salvianolic acid B Bioavailability Blood viscosity Beagle dogs |
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