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24例难治性颞叶癫痫手术患者病例分析
作者姓名:张豪正  李堃  于华凤  王广新  孟姣  陈洁
作者单位:山东大学公共卫生学院儿少卫生与妇幼保健系 济南250012;济南市儿童医院儿科医学研究所 济南250022;山东省淄博昌国医院神经科 淄博255000;济南市儿童医院儿内科 济南250022;济南市中心医院专科转化研究中心 济南250013;济南市儿童医院病理科 济南250022;山东大学公共卫生学院儿少卫生与妇幼保健系 济南250012
基金项目:山东省自然科学基金项目(ZR2019MH043);济南市临床科技创新计划(201705031)。
摘    要:目的 了解难治性颞叶癫痫手术治疗的现状和预后效果.方法 回顾性分析2011年4月-2014年6月于淄博昌国医院经手术治疗且临床及随访资料完整的24例难治性颞叶癫痫手术患者,其中男14例,女10例.年龄16~44岁,平均(24.40±6.26)岁,平均病程(12.50±8.42)年.分析患者的临床特点和预后情况.结果 2...

关 键 词:难治性癫痫  海马硬化  手术

Analysis of 24 cases of intractable temporal lobe epilepsy surgery
Authors:ZHANG Haozheng  LI Kun  YU Huafeng  WANG Guangxin  MENG Jiao  CHEN Jie
Institution:(Department of Maternal and Child Health,School of Public Health,Shandong University,Jinan 250012,China;Pediatric Research Institute,Jinan Children's Hospital,Jinan,Shandong 250022,China;Department of Neurology,Changguo Hospital,Zibo,Shandong 250022,China;Pediatric Internal Medicine Department,Jinan Children's Hospital,Jinan,Shandong 250022,China;Institute of Translational Medicine,Jinan Central Hospital Affiliated to Shandong University,Jinan,Shandong 250022,China;Pathology Department,Jinan Children's Hospital,Jinan,Shandong 250022,China)
Abstract:Objective To investigate the status and prognosis effect of surgical operation for Temporal lobe epilepsy. Methods Retrospective analyses were performed on 24 patients with intractable temporal lobe epilepsy who were treated by surgery in Zibo Changguo Hospital and had complete clinical and follow-up data, during the period from April 2011 to June 2014. Among them, 14 were male and 10 were female, 16 to 44 years old, the average age was(24.40±6.26)years old, and the average course of disease was(12.50±8.42) years old. The clinical characteristics and prognosis of the patients were analyzed. Results All 24 patients had hippocampal sclerosis and underwent "anterior temporal lobe and medial temporal structural resection". Patients were followed up for 5~7 years, the postoperative epileptic seizure of the patient reached grade Engel Ⅰ in 20 cases(83.3%), grade Engel Ⅱ in 2 cases(8.3%) and grade Engel Ⅳ in 2 cases(8.3%). Conclusion Hippocampal sclerosis and cortical dysplasia were common in 24 patients, and the operation controlling intractable epilepsy was better. In order to improve the prognosis of patients, surgical treatment should be carried out as soon as possible.
Keywords:Intractable epilepsy  Hippocampal sclerosis  Surgery
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