Physiologie und Biochemie der Streptomyceten XIII. Biosynthese von Paromomycin unter Einsatz von 14C-Glucose, -Glucosamin, -2-Desoxystreptamin und -Ribose durch Streptomyces albus var. metamycinus nov. var.

Distribution of radioactivity in paromomycin ascertained after application of ¹⁴C-D-glucose, ¹⁴C-D-glucosamine, ¹⁴C-2-deoxystreptamine, respectively, ¹⁴C-D-ribose is taken as basis for a biosynthesis scheme: While ribose bound in the antibiotic originates from glucose by oxidation and following decarboxylation, glucosamine is formed via fructose-6-phosphate. Paromose I arises from glucosamine, but not the cyclohexan derivative 2-deoxystreptamine, whose biosynthesis pathway is directly branching off glucose.