| 罗布麻叶总黄酮提取物对小鼠的抗抑郁作用的研究 |
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| 引用本文： | 郑梅竹,刘春明,胡薇,时东方,张语迟,吴桂梅. 罗布麻叶总黄酮提取物对小鼠的抗抑郁作用的研究[J]. 时珍国医国药, 2011, 22(10): 2319-2321. DOI: 10.3969/j.issn.1008-0805.2011.10.002 |
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| 作者姓名： | 郑梅竹 刘春明 胡薇 时东方 张语迟 吴桂梅 |
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| 作者单位： | 1. 长春师范学院中心实验室,吉林长春,130032
2. 吉林农业大学生命科学院,吉林长春,130118 |
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| 基金项目： | 国家自然科学基金(No.30970299); 吉林省科技厅重点项目(No.20090936) |
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| 摘 要： | 目的对传统中药罗布麻进行抗抑郁活性评价,并对其作用机制进行研究。方法采用经典抗抑郁评价模型小鼠强迫游泳实验对罗布麻叶总黄酮进行抗抑郁活性评价,在此基础上,应用皮质酮损伤PC12细胞模型,采用MTT法、LDH检测法观察罗布麻提取物对皮质酮损伤的PC12细胞是否具有神经保护作用。结果在小鼠强迫游泳实验中,罗布麻提取物100,50,26 mg/kg(i.g.)连续给药10 d后,能显著缩短小鼠的强迫游泳不动时间(分别为P<0.001,P<0.05,P<0.01);同时罗布麻叶总黄酮提取物对皮质酮损伤的PC12细胞具有神经保护作用。结论罗布麻叶总黄酮具有抗抑郁作用,其机理可能与神经细胞的保护作用有关。
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| 关 键 词： | 罗布麻叶总黄酮提取物 皮质酮 抗抑郁 |
Antidepressant Effect of Flavonoid Extract from Apocynum venetum Leaves in Mice |
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| ZHENG Mei-zhu,LIU Chun-ming,HU Wei,SHI Dong-fang,ZHANG Yu-chi,WU Gui-mei. Antidepressant Effect of Flavonoid Extract from Apocynum venetum Leaves in Mice[J]. Lishizhen Medicine and Materia Medica Research, 2011, 22(10): 2319-2321. DOI: 10.3969/j.issn.1008-0805.2011.10.002 |
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| Authors: | ZHENG Mei-zhu LIU Chun-ming HU Wei SHI Dong-fang ZHANG Yu-chi WU Gui-mei |
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| Affiliation: | ZHENG Mei-zhu1,LIU Chun-ming1*,HU Wei2,SHI Dong-fang1,ZHANG Yu-chi1,WU Gui-mei1(1.The Central Laboratory,Changchun Normal University,Changchun 130032,China,2.Department of Biochemistry,College of Life Science,Jilin Agricultural University,Changchun 130118,China) |
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| Abstract: | ObjectiveTo study the antidepressant-like effect of traditional Chinese medicine(TCM),Apocynum venetum and its corresponding mechanisms. MethodsThe classical animal model of depression-the forced swimming test was adopted to evaluate the antidepressant effect of flavonoid extract from Apocynum venetum leaves(AV-extract),and the neuroprotective effect of AV extract was studied in corticosterone-induced neurotoxicity in PC12 cells AV extract by MTT and lactic dehydrogenase(LDH) assay. ResultsThe results showe... |
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| Keywords: | Apocynum Venetum extract Corticosterone Antidepressants |
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