| 抗中性粒细胞胞质抗体相关性间质性肾炎 |
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| 引用本文： | 徐峰,曾彩虹. 抗中性粒细胞胞质抗体相关性间质性肾炎[J]. 肾脏病与透析肾移植杂志, 2011, 20(3): 285-289 |
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| 作者姓名： | 徐峰 曾彩虹 |
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| 作者单位： | 南京军区南京总医院，全军肾脏病研究所，南京，210002 |
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| 摘 要： | 49岁女性,主要表现为乏力、贫血、肾功能不全,无蛋白尿、血尿,无咯血等肺部表现,血核周型抗中性粒细胞胞质抗体(pANCA)阳性,弹性蛋白酶ANCA阳性。肾活检组织学表现为间质性肾炎,伴肾小球废弃,非废弃肾小球病变轻微。免疫病理示寡免疫复合物沉积,经甲泼尼龙和环磷酰胺治疗后,血ANCA转阴,重复肾活检肾小管间质急性病变亦明显减轻,肾功能明显改善,综合临床、实验室检查及组织学特点,最终诊断为ANCA相关性间质性肾炎。
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| 关 键 词： | 间质性肾炎 抗中性粒细胞胞质抗体 肾活检 |
Anti-neutrophil cytoplasmic antibodies (ANCA) associated tubulointerstitial nephritis |
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| XU Feng,ZENG Cai-hong. Anti-neutrophil cytoplasmic antibodies (ANCA) associated tubulointerstitial nephritis[J]. Chinese Journal of Nephrology, Dialysis & Transplantation, 2011, 20(3): 285-289 |
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| Authors: | XU Feng ZENG Cai-hong |
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| Affiliation: | XU Feng,ZENG Cai-hong Research Institute of Nephrology,Jinling Hospital,Nanjing University School of Medicine,Nanjing 210002,China |
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| Abstract: | A 49-year female was admitted because of fatigue,anemia,decreased renal function for six months.Serum pANCA and Elastase ANCA were positive.The renal biopsy was performed and histological examination demonstrated tubulointerstitial nephritis with some obsolescent,but otherwise near normal glomeruli.Immunofluorescence study indecated panci-immune deposits.The extensive investigations showed no signs of granulomatous inflammation or other vasculitic organ involvement.After immunosupressive treatment,serum ANC... |
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| Keywords: | tubulointerstitial neprhitis anti-neutrophil cytoplasmic antibodies renal biopsy |
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