| 四君子汤预处理抗氧化改善梗塞大鼠心功能的实验研究 |
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| 引用本文： | 钱海兵,黄勇其,王毅. 四君子汤预处理抗氧化改善梗塞大鼠心功能的实验研究[J]. 时珍国医国药, 2011, 22(9). DOI: 10.3969/j.issn.1008-0805.2011.09.090 |
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| 作者姓名： | 钱海兵 黄勇其 王毅 |
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| 作者单位： | 1. 贵阳中医学院,贵州,贵阳,550002
2. 成都中医药大学,四川,成都,610074 |
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| 摘 要： | 目的 探讨四君子汤预处理对大鼠急性心肌梗塞后心功能的影响及其相关机制.方法 在四君子汤预处理基础上,结扎雄性大鼠左冠状动脉,复制心肌梗塞模型,分为四君子汤高、低剂量组,另设阳性对照预处理组、模型组、假手术组.术后2d检测大鼠心功能、心肌肥厚指数以及心肌组织谷胱甘肽过氧化物酶(GSH-Px)和过氧化氢酶(CAT)活性.结果 模型组心功能、GSH-Px和CAT活性较其他各组均降低,心肌肥厚指数增加,四君子汤高剂量组及阳性对照组可以明显改善梗塞后心功能、提高GSH-Px和CAT活性,降低心肌肥厚指数,与模型组比较具有显著意义.结论 四君子汤具有改善梗塞后心功能,减缓心肌重构的作用,其机制可能与其抗氧化作用有关.
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| 关 键 词： | 四君子汤 心肌梗塞 心功能 谷胱甘肽过氧化物酶 过氧化氢酶 |
Influence of Si Junzi Decoction on Cardiac Function after Myocardial Infarction in Rats |
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| QIAN Hai-bing,HUANG Yong-qi,WANG Yi. Influence of Si Junzi Decoction on Cardiac Function after Myocardial Infarction in Rats[J]. Lishizhen Medicine and Materia Medica Research, 2011, 22(9). DOI: 10.3969/j.issn.1008-0805.2011.09.090 |
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| Authors: | QIAN Hai-bing HUANG Yong-qi WANG Yi |
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| Affiliation: | QIAN Hai-bing1,HUANG Yong-qi1,WANG Yi2 (1.Guiyang College of TCM,Guiyang 550002,Guizhou,2.Chengdu University of TCM,Chengdu 610074,Sichuan) |
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| Abstract: | Objective To investigate the effect of Si Jun-zi Decoction on cardiac function of rats after myocardial infarction and its mechanism. Methods Sprague-Dawley rats were randomly divided into 5 groups and subjected to ligation of anterior descending branch of coronary artery :Sham operation group model group,Si Jun-zi Decoction preconditioning group(High and low doses);positive control group.Aftere 2 days,myocardial hypertrophy index,cardiac function,glutathione peroxidase and catalase were determined. Results... |
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| Keywords: | Si Jun-zi Decoction Myocardial infarction Cardiac function Glutathione peroxidase Catalase |
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