| 炮制前后隔山消对荷S180肉瘤小鼠的影响 |
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| 引用本文： | 孙佳强,邓旭坤,刘刚,赵湘培,梅之南.炮制前后隔山消对荷S180肉瘤小鼠的影响[J].时珍国医国药,2011,22(9):2095-2097. |
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| 作者姓名： | 孙佳强 邓旭坤 刘刚 赵湘培 梅之南 |
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| 作者单位： | 中南民族大学药学院,湖北,武汉,430074 |
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| 摘 要： | 目的比较炮制前后隔山消对荷S180肉瘤小鼠的抑瘤率和毒性。方法 KM小鼠接种S180瘤株造成荷瘤小鼠模型。观察比较隔山消生品及两种炮制品的水提物的抑瘤率和毒性。结果 3种水提物对小鼠S180肉瘤的最大抑制率分别为54.64%5,4.22%和46.93%。无明显毒性。结论隔山消炮制前后均对小鼠S180肉瘤有一定抑制作用,且无明显的毒性。
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| 关 键 词： | 炮制 隔山消 小鼠S180肉瘤 抑瘤率 毒性 |
Influence of Different Processing Methods of Cynanchum auriculatum on S180 Mice |
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| SUN Jia-qiang,DENG Xu-kun,LIU Gang,ZHAO Xiang-pei,MEI Zhi-nan.Influence of Different Processing Methods of Cynanchum auriculatum on S180 Mice[J].Lishizhen Medicine and Materia Medica Research,2011,22(9):2095-2097. |
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| Authors: | SUN Jia-qiang DENG Xu-kun LIU Gang ZHAO Xiang-pei MEI Zhi-nan |
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| Institution: | SNU Jia-qiang,DENG Xu-kun,LIU Gang,ZHAO Xiang-pei,MEI Zhi-nan(College of Pharmacology,South-central University for Nationalities,Wuhan 430074,China) |
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| Abstract: | Objective To observe the influence of different processing methods of Cynanchum auriculatum Royleex Wight(RCA) on in vivo anti-tumor activity to S180 tumor and the toxicity in mice. Methods The tumor model was established by subcutaneous injection with S180 tumor cells in KM mice.The tumor inhibitory ratio and the toxicity of RCA were observed. Results The maximum tumor inhibitory ratio of three kinds of water extracts from RCA were 54.64 %,54.22 % and 46.93%,respectively.No significant toxicity was shown. ... |
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| Keywords: | Different processing methods Cynanchum auriculatum Royleex Wight S180 tumor Anti-tumor activity Toxicity |
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