| 天然冰片小鼠急性毒性的时间毒理学研究 |
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| 引用本文： | 李伟荣,刘睿,黄天来,许庆文,宓穗卿,王宁生.天然冰片小鼠急性毒性的时间毒理学研究[J].时珍国医国药,2011,22(8):1805-1806. |
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| 作者姓名： | 李伟荣 刘睿 黄天来 许庆文 宓穗卿 王宁生 |
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| 作者单位： | 广州中医药大学临床药理研究所,广东广州,510405 |
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| 基金项目： | 国家自然科学基金，广州中医药大学师资队伍建设科研项目 |
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| 摘 要： | 目的研究小鼠口服天然冰片后急性毒性的昼夜差异。方法小鼠随机分为白昼组和黑夜组,每组60只,分别于不同时间给予不同剂量的天然冰片,观察死亡情况,计算LD50值。结果 白昼组的LD50为2 425.9 mg/kg,95%可信区间为1939.5～2 940.6 mg/kg;黑夜组的LD50为2 307.3 mg/kg,95%可信区间为1 555.6～2 948.2 mg/kg,白昼组LD50大于黑夜组。结论 天然冰片对小鼠的急性毒性存在昼夜差异,明期(小鼠休息期)毒性小于暗期(小鼠活动期)。
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| 关 键 词： | 天然冰片 急性毒性 小鼠 时间毒理学 |
Chronotoxicology Study of Acute Toxicity on Natural Borneol in Mice |
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| LI Wei-rong,LIU Rui,HUANG Tian-lai,XU Qing-wen,MI Sui-qing,WANG Ning-sheng.Chronotoxicology Study of Acute Toxicity on Natural Borneol in Mice[J].Lishizhen Medicine and Materia Medica Research,2011,22(8):1805-1806. |
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| Authors: | LI Wei-rong LIU Rui HUANG Tian-lai XU Qing-wen MI Sui-qing WANG Ning-sheng |
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| Institution: | LI Wei-rong,LIU Rui,HUANG Tian-lai,XU Qing-wen,MI Sui-qing,WANG Ning-sheng*(Institute of Clinical Pharmacology,Guangzhou University of Chinese Medicine,Guangzhou 510405,China) |
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| Abstract: | Objective To study the difference of acute toxicity between day and night after oral administration of natural borneol in mice.Methods Mice were randomly divided into day group and night group(n=60),at different time points with different doses of natural borneol,the mortality was observed and the half lethal dose(LD50) was calculated.Results The LD50 of day group was 2 425.9mg/kg,95% confidence interval was 1 939.5~2 940.6 mg/kg;the LD50 of night group was 2 307.3 mg/kg,95% confidence interval was 1 555.6~... |
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| Keywords: | Natural borneol Acute toxicity Mice Chronotoxicology |
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