| 知柏养阴汤对阴虚模型大鼠糖脂代谢的影响 |
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| 引用本文： | 林昌松,李宁,徐强,王笑丹,李小兵,陈纪藩. 知柏养阴汤对阴虚模型大鼠糖脂代谢的影响[J]. 时珍国医国药, 2011, 22(10). DOI: 10.3969/j.issn.1008-0805.2011.10.037 |
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| 作者姓名： | 林昌松 李宁 徐强 王笑丹 李小兵 陈纪藩 |
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| 作者单位： | 广州中医药大学第一附属医院,广东广州,510405 |
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| 基金项目： | 广东省自然科学基金(No.8151040701000031) |
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| 摘 要： | 目的 观察知柏养阴汤对糖皮质激素型阴虚大鼠糖脂代谢的影响.方法 将SD大鼠30只随机分为空白组、模型组及中药组,每组各10只.用氢化可的松塑造激素型阴虚大鼠模型,对模型组灌胃生理盐水,对中药组用知柏养阴汤进行灌胃治疗,8d后检测3组大鼠血清中总胆固醇(CHOL)、甘油三酯(TG)、高密度脂蛋白(HDL- C)、低密度脂蛋白( LDL - C)及空腹血糖(GLU)的浓度进行比较.结果 激素模型组、中药治疗组较之空白组GLU、TG、CHOL、HDL -C均升高,其中CHOL、HDL -C升高明显(P＜0.05).中药组应用知柏养阴汤后,较之激素模型组GLU、CHOL、TG、HDL -C、LDL -C均降低,其中GLU、CHOL降低较明显(P＜0.05).结论 激素型阴虚模型大鼠存在一定程度的糖脂代谢异常；知柏养阴汤可以改善阴虚症状,具有降低糖皮质激素导致的高血糖、高血脂的作用.
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| 关 键 词： | 知柏养阴汤 糖皮质激素 阴虚 糖脂代谢 |
Effect of Zhibai Yangyin Decoction on Glucose and Lipid Metabolism of Rats with Yindeficiency Induced by Glucocorticosteroid |
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| LIN Chang-song,LINing,XU Qiang,WANG Xiao-dan,LI Xiao-bing,CHEN Ji-fan. Effect of Zhibai Yangyin Decoction on Glucose and Lipid Metabolism of Rats with Yindeficiency Induced by Glucocorticosteroid[J]. Lishizhen Medicine and Materia Medica Research, 2011, 22(10). DOI: 10.3969/j.issn.1008-0805.2011.10.037 |
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| Authors: | LIN Chang-song LINing XU Qiang WANG Xiao-dan LI Xiao-bing CHEN Ji-fan |
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| Affiliation: | LIN Chang-song,LI Ning,XU Qiang,WANG Xiao-dan,LI Xiao-bing,CHEN Ji-fan(The First Affiliated Hospital of Guangzhou University of TCM,Guangzhou 510405,China) |
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| Abstract: | ObjectiveTo observe the effect of Zhibai Yangyin Decoction on glucose and lipid metabolism of rats with Yin-deficiency induced by glucocorticosteroid. MethodsThirty SD rats were randomly divided into three groups: normal control group,model group and TCM treatment group(n=10).The Yin deficient model was induced by glucocorticosteroid,and the TCM group were administered intragastrically with Zhibai Yangyin Decoction.After 8 days,all rats were executed the concentrations of total cholesterol(CHOL),triglycerid... |
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| Keywords: | Zhibai Yangyin Decoction Glucocorticosteroid Yin-deficiency Glucose and lipid metabolism |
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