| 四氧嘧啶糖尿病小鼠模型的复制与应用体会 |
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| 引用本文： | 黄彦峰,晋玲,赵善民,刘波,黄永毅.四氧嘧啶糖尿病小鼠模型的复制与应用体会[J].时珍国医国药,2011,22(11). |
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| 作者姓名： | 黄彦峰 晋玲 赵善民 刘波 黄永毅 |
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| 作者单位： | 右江民族医学院机能实验教学中心,广西百色,533000 |
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| 基金项目： | 广西壮族自治区自然科学基金 |
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| 摘 要： | 目的 探讨糖尿病小鼠模型复制过程中出现的影响因素并对解决这些影响因素进行分析.方法 用四氧嘧啶复制糖尿病模型,在复制过程中,就动物的种类、性别、给药的途径、剂量,血糖测值、测糖选时等进行观察比较.结果 经模型复制发现,由于动物的种类、性别、给药的途径、剂量不同等因素,会给模型复制产生不同的影响.结论 由于多种因素的影响,四氧嘧啶糖尿病模型复制时应引起注意.
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| 关 键 词： | 四氧嘧啶 糖尿病模型 小鼠 影响因素 |
Replication and Application Experience of Alloxan- induced Diabetic Mouse Model |
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| HUANG Yan-feng,JIN Ling,ZHAO Shan-min,LIU Bo,HUANG Yong-yi.Replication and Application Experience of Alloxan- induced Diabetic Mouse Model[J].Lishizhen Medicine and Materia Medica Research,2011,22(11). |
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| Authors: | HUANG Yan-feng JIN Ling ZHAO Shan-min LIU Bo HUANG Yong-yi |
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| Institution: | HUANG Yan-feng,JIN Ling*,ZHAO Shan-min,LIU Bo,HUANG Yong-yi (The Functional Experiment Teaching Center of Youjiang Medial College for Nationalities,Baise 533000 China) |
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| Abstract: | Objective To explore and analyze the factors appeared in process of replicated diabetic mouse model. Methods Diabetic model was replicated with alloxan.The animal species,sex,drug deliveried means,dosage,blood glucose values and the test time were observed and compared. Results The replicated model indicated that all the factors including the animal species,sex,drug diliveried approach,dosage,etc.could lead to different influences. Conclusion The process replicated diabetic model with alloxan should be atte... |
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| Keywords: | Alloxan Diabetes models Mice Affecting factors Experience |
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