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| 利用血液微透析技术进行芎冰喷雾剂的药动学研究 | |
| 引用本文： | 叶勇,晏亦林,周莉玲,黄秋洁.利用血液微透析技术进行芎冰喷雾剂的药动学研究[J].时珍国医国药,2011,22(11):2573-2575. |
| 作者姓名： | 叶勇 晏亦林 周莉玲 黄秋洁 |
| 作者单位： | 1. 广州中医药大学,广东广州510006;广西医科大学,广西南宁530021 2. 广东食品药品职业学院,广东广州,510520 3. 广州中医药大学,广东广州,510006 4. 广西中医学院,广西南宁,530001 |
| 基金项目： | 国家自然科学基金，广东省自然科学基金，广州市科技攻关重点项目 |
| 摘 要： | 目的探讨采用血液微透析技术研究芎冰喷雾剂药动学的可行性和优越性。方法大鼠鼻腔或静脉注射给予芎冰喷雾剂后,利用血液微透析技术进行药动学研究,高效液相色谱法测定透析液样品中磷酸川芎嗪(TMPP)的浓度,用Das2.0药动学软件计算主要药动学参数。结果鼻腔给药和静注给药后TMPP的吸收均符合二室模型,芎冰喷雾剂鼻腔给药有一定优势。结论采用血液微透析技术进行芎冰喷雾剂的药动学研究方法可行,与传统方法相比,具有明显的优势。 |
| 关 键 词： | 芎冰喷雾剂 磷酸川芎嗪 血液微透析 药动学 |
Pharmacokinetics Study on Xiongbing Nasal Spray in Rats by Blood Microdialysis Technique |
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| YE Yong,YAN Yi-lin,ZHOU Li-ling,HUANG Qiu-jie.Pharmacokinetics Study on Xiongbing Nasal Spray in Rats by Blood Microdialysis Technique[J].Lishizhen Medicine and Materia Medica Research,2011,22(11):2573-2575. | |
| Authors: | YE Yong YAN Yi-lin ZHOU Li-ling HUANG Qiu-jie |
| Institution: | YE Yong 1,2,YAN Yi-lin 3*,ZHOU Li-ling1,HUANG Qiu-jie4 (1.Guangzhou University of Traditional Chinese Medicine,Guangzhou 510006,China,2.Guangxi Medical University,Nanning 530021,3.Guangdong Food and Drug Vocational College,Guangzhou 510520,4.Guangxi University of TCM,Nanning 530001,China) |
| Abstract: | Objective To explore the feasibility and advantages of blood microdialysis technique for the pharmacokinetic study on Xiongbing nasal spray in rats. Methods The pharmacokinetic behavior of tetramethylpyrazine phosphate(TMPP) in rats was investigated after intranasal or intravenous administration of Xiongbing nasal spray.Samples were collected by blood microdialysis,and the concentrations of TMPP in the samples was determined by HPLC.After the dialysate concentration was calibrated,main pharmacokinetic param... |
| Keywords: | Xiongbing nasal spray Tetramethylpyrazine phosphate(TMPP) Blood microdialysis Pharmacokinetics |
| 本文献已被 CNKI 万方数据 等数据库收录！ | |