重组人碱性成纤维细胞生长因子与磺胺嘧啶银霜联合应用对慢性难愈性创面愈合过程的修复效应

目的：探讨联合应用重组人碱性成纤维细胞生长因子与磺胺嘧啶银霜对慢性难愈性创面愈合过程的影响。方法：选取2008年7月至2013年3月在本院住院治疗的各种慢性难愈性创面患者80例，随机分为常规治疗组（A组）20例、重组人碱性成纤维细胞生长因子治疗组（B组）20例、磺胺嘧啶银治疗组（C组）20例和重组人碱性成纤维细胞生长因子与磺胺嘧啶银联合治疗组（D组）20例。记录各组创面愈合时间，伤后3d起隔日计算4组的创面愈合百分率。结果：D组创面愈合时间较其他3组明显缩短（P〈0．05）。伤后第7、第11、第14、第17、第2l天D组创面愈合率高于其他组（P〈0．05）。结论：重组人碱性成纤维细胞生长因子与磺胺嘧啶银联合应用可促进慢性难愈性创面愈合。

Prosthetic effect of recombinant human basic fibroblast growth factor combined with silvadene cream on the healing of chronic and refractory wound

Objective： To explore and discuss the therapeutic effect of chronic and refractory wound by recombinant human basic fibroblast growth factor combined with silvadene cream. Methods： Eighty cases with chronic and refractory wound were selected from Lishui People＇s Hospital between July 2008 and March 2013. These patients were randomly divided into 4 groups： group A receiving regular therapy, group B receiving recom- binant human basic fibroblast growth factor, group C receiving silvadene cream, group D receiving recombinant human basic fibroblast growth factor combined with silvadene cream, 20 patients in each group. The wound healing period and the wound healing rates in the 4 groups were recorded. Results： As compared with group A, B, and C, the wound healing period was significantly decreased （P〈0.05）, the wound healing rate in day 7, 11, 14, 17, and 21 was obviously inereased （P〈0.05）. Conclusion： Recombinant human basic fibroblast growth factor combined with silvadene cream can promote the healing of chronic and refractory wound.