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| 前庭神经核内谷氨酸受体在帕金森病的变化 | |
| 引用本文： | 孙安,陈文弦,李广琪,陈良为,叶维莉,江逊,赵大庆. 前庭神经核内谷氨酸受体在帕金森病的变化[J]. 中国神经精神疾病杂志, 2003, 29(4): 255-257 |
| 作者姓名： | 孙安 陈文弦 李广琪 陈良为 叶维莉 江逊 赵大庆 |
| 作者单位： | 1. 第四军医大学唐都医院耳鼻咽喉科,现在武警陕西总队医院耳鼻喉科,西安,710054 2. 武警陕西总队医院耳鼻喉科 3. 第四军医大学神经生物研究所 |
| 摘 要： | 目的 探讨前庭神经核内离子型谷氨酸受体在帕金森病时的变化。方法 采用免疫组织化学染色技术检测小鼠前庭神经核内谷氨酸受体的表达。结果 在帕金森病时,前庭神经核内N-甲基-D-天门冬氨酸(NMDA)受体增加,非NMDA受体减少。结论 非NMDA受体在帕金森病中起神经毒性作用,引起相应病理改变,推测其变化与临床运动障碍、平衡失调有一定关系。 |
| 关 键 词： | 前庭神经核 谷氨酸受体 帕金森病 免疫组织化学 |
| 修稿时间： | 2002-07-30 |
Changes of glutamate receptors on vestibular nuclei of Parkinson''s disease |
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| Sun An,Chen Wenxian,Li Guangqi,ChenLiangwei,Ye Weili,Jiang Xun,Zhao Daqing. Changes of glutamate receptors on vestibular nuclei of Parkinson''s disease[J]. Chinese Journal of Nervous and Mental Diseases, 2003, 29(4): 255-257 | |
| Authors: | Sun An Chen Wenxian Li Guangqi ChenLiangwei Ye Weili Jiang Xun Zhao Daqing |
| Affiliation: | Sun An,Chen Wenxian,Li Guangqi,ChenLiangwei,Ye Weili,Jiang Xun,Zhao Daqing. Department of Otorhinolaryngology,Tandu Hospital,Chinese Fourth Military Medical Univeristy,Xinsi Road,Xi'an. 710054. Tel: 029-2232524-37090 |
| Abstract: | Objective To investigate the changes of glutamate receptors in vestibular nuclei on Parkinson's disease. Mefll-ods Immunohistoehemical staining method was used in the present studv to detected glutamate receptors expression in vestibular nuclei. Results NMDA receptor expression Ievel was higher in vestibular nuclei, but non-NMDA receptor was lawer in vestibular nuclei of Parkinson's disease. Conclusions The results sugges that the non-NMDA receptor might be injure caused vestibular neu-rons of Parkinson's disease by excitoxicity and dyskinetic, dysequilibrium and relatetion the changes of pathology. |
| Keywords: | Vestibular nucleus Glutamate receptor Parkinson's disease Immunohistochemical |
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