联合应用胺碘酮与替米沙坦治疗阵发性心房颤动125例临床观察

目的:评价胺碘酮与替米沙坦联合应用治疗阵发性心房颤动的临床疗效.方法:将阵发性房颤患者(125例)随机分为胺碘酮治疗组(63例)和胺碘酮+替米沙坦组(62例).首次治疗后,进行16个月随访.比较两组治疗后4,8,12,16个月的窦性心律维持率和治疗前、治疗后8,12,16个月的左房前后径.结果:治疗后4个月,胺碘酮治疗组窦性心律维持率为88.5%,与胺碘酮加替米沙坦治疗组(90.2%)比较无统计学差异(P>0.05).治疗后8,12,16个月,胺碘酮治疗组窦性心律维持率分别为67.2%,62.3%,59.0%,胺碘酮加替米沙坦治疗组分别为88.3%,86.7%,83.3%,两组差异均有统计学意义(P<0.01).而治疗12个月后,胺碘酮治疗组左心房前后径明显大于胺碘酮加替米沙坦治疗组(P<0.05).结论:胺碘酮与替米沙坦联合治疗组患者的窦性心律维持率高于单纯胺碘酮治疗组,联合用药还可有效控制左心房扩大.

Clinical Observations of Amiodaronein and Telmisartan in Treating 125 Cases of Paroxysm Atrial Fibrillation

Objective:To investigate the effect of combination of telmisartan and amiodaronein in patients with paroxysm atrial fibrillation.Methods: 125 patients with paroxysmal atrial fibrillation were randomly divided into 2 groups :Groupl(amiondarone group,n=63) and group 2(telmisartan and amiodaronein group,n=62).After 16 months follow up,the maintenance rate of sinus rhythm was measured in the fourth,eighth,twelfth,sixteenth months,and the left atrail diameter was measured before treatment and eighth months after...