| 神经营养因子及其受体的基因突变与疾病 |
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| 引用本文： | 朱伟,路长林,何成.神经营养因子及其受体的基因突变与疾病[J].中国神经科学杂志,2004,20(1):71-77. |
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| 作者姓名： | 朱伟 路长林 何成 |
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| 作者单位： | 第二军医大学神经生物学教研室,上海200433 |
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| 摘 要： | 神经营养因子在神经系统发育和生理功能发挥中具有重要作用。神经营养因子及其受体的基因缺失及突变是导致某些人类疾病，如各种先天性发育不全、神经退行性疾病和癌症等的“候选基因”或“修饰基因”，本文综述了神经营养因子及其受体突变与疾病的关系。
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| 关 键 词： | 神经营养因子 神经营养因子受体 基因突变 疾病 基因缺失 |
Mutations of neurotrophic factors and neurotrophic factor receptors in human diseases |
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| ZHU Wei,LU Chang-lin,HE Cheng.Mutations of neurotrophic factors and neurotrophic factor receptors in human diseases[J].Neuroscience Bulletin,2004,20(1):71-77. |
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| Authors: | ZHU Wei LU Chang-lin HE Cheng |
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| Abstract: | Neurotrophic factors are critical to the development and function of the nervous system. Mutations of neurotrophic factors and their receptors will lead to many human diseases, such as agenesis, neurodegenerative disorder and cancer. This paper reviews the "candidate genes" and "modifier candidate genes" of neurotrophic factors and their receptors related to human diseases. |
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| Keywords: | neurotrophic factor neurotrophic factor receptor mutation |
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