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Correlation between a reduction in Frontal Assessment Battery scores and delusional thoughts in patients with Alzheimer's disease |
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| Authors: | Tomoyuki Nagata md Kazuhiro Ishii md Tatsuhiko Ito md Kimiyoshi Aoki md Yoshito Ehara md Hidehiro Kada md Haruko Furukawa cp Maki Tsumura cp Shunichiro Shinagawa md phd Hiroo Kasahara md phd and Kazuhiko Nakayama md phd |
| Institution: | Department of Psychiatry, Jikei University School of Medicine, Kashiwa Hospital, Chiba and;Department of Psychiatry, Jikei University School of Medicine, Tokyo, Japan |
| Abstract: | Aims: The purpose of the present study was to investigate the relationship between delusional thoughts (delusional ideation or misidentification) and frontal lobe function using the Japanese version of the Frontal Assessment Battery (FAB) bedside screening neuropsychological test in early stage Alzheimer's disease (AD) patients. Methods: Forty-eight probable AD patients with Mini-Mental State Examination score ≧18 points and a clinical dementia rating score of either 0.5 or 1.0 were divided into two groups based on data obtained from interviews with their caregivers: a delusional thought group ( n = 19) and a non-delusional thought group ( n = 29). The FAB total and subtest scores were then compared for the two groups. Results: Significant differences were found between the FAB total ( P < 0.01) and subtest scores (similarities, motor series, conflicting instructions; P < 0.05) for the two groups. Multiple regression analysis showed that delusional thought was significantly associated with the FAB total score. Conclusions: In addition to episodic memory disorders, a reduction in the FAB score may reflect frontal lobe dysfunctions, including executive function, in patients with AD, leading to delusional ideation. |
| Keywords: | Alzheimer's disease delusional ideation Frontal Assessment Battery misidentification |