附子减毒与药效探析

目的：探析附子减毒与药效的关系。方法：对附子炮制减毒、配伍减毒、先煎减毒、久煎减毒等方法对药效的影响进行分析。结果：发现不同附子炮制品的毒性和疗效是不同的,炮制和久煎能降低附子的毒性,但存在炮制、久煎减毒过度倾向;附子合理的配伍可减毒增效,但它的药效仍受附子炮制品的影响。结论：在对附子进行减毒的同时应注意存效和增效,建议应该寻求一种高效低毒的炮制品作为附子的法定炮制品,可使附子在安全范围内发挥最佳药效。

Discussion and Analysis Between the Attenuation of Prepared Aconite Root and Its Drug Effects

Objective ： To explore the relationship between the attenuation of prepared aconite root and its drug effects. Methods： Analyze the drug effect of prepared aconite root by processing and compatibling drugs, decocting, it first and lasting for a long time in order to at- tenuate it. Results ： We found that different processed products have its own attenuation and curative effects. Processing drugs and boiling the medicinal drugs for a long time will reduce the toxicity of prepared aconite root,but may be over-done ;Prepared aconite root＇s rea- sonable compatibility can attenuated efficiency, but aconite processed products can still have an impact on its drug effects. Conclusion： When reducing prepared aconite root＇s toxicity,we should take care of saving efficacy and its synergia, it suggest that we find an effi- ciency and low toxicity processed product as statutory processed product of prepared aconite root which will make prepared aconite root educe best drug effects within safety limits.