The compartment model for chronically implanted voltammetric electrodes in the rat brain |
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Authors: | W J Albery M Fillenz R D O''Neill |
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Affiliation: | 1. University Laboratory of Physiology, South Parks Road, Oxford OX1 3PT, U.K.;2. Department of Chemistry, Imperial College, London SW7 2AY U.K. |
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Abstract: | Diazepam (0.4-0.8 mg/kg i.p.) reduced the spontaneous activity in the electromyogram (EMG) recorded from the gastrocnemius-soleus muscle of spastic mutant Han--Wistar rats in a dose-dependent manner. The depressant effect of diazepam (0.8 mg/kg) on the EMG activity was antagonized by Ro 15-1788 (5 mg/kg i.p.) and by picrotoxin (2 mg/kg i.p.), but not by bicuculline (2 mg/kg i.p.). These results suggest that diazepam depresses EMG activity of mutant rats by mechanisms related to the interaction of the drug with GABA-independent benzodiazepine receptors. |
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Keywords: | linear sweep voltammetry rat brain acute and chronic theoretical treatment compartment model |
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