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Epithelial mesenchymal transition and hedgehog signaling activation are associated with chemoresistance and invasion of hepatoma subpopulations
Authors:Chen Xiaoli  Lingala Shilpa  Khoobyari Shiva  Nolta Jan  Zern Mark A  Wu Jian
Affiliation:1Department of Internal Medicine, Division of Gastroenterology and Hepatology, University of California, Davis Medical Center, Sacramento, CA 95817, United States;2Stem Cell Program, University of California, Davis Medical Center, Sacramento, CA 95817, United States;3Cancer Center, University of California, Davis Medical Center, Sacramento, CA 95817, United States
Abstract:
Keywords:Abbreviations: ALDH, aldehyde dehydrogenase   APC, allophycocyanin   CPM, cyclopamine   CSCs, cancer stem cells   DAPI, 4&prime  ,6-diamidino-2-phenylindole   EMT, epithelial mesenchymal transition   FACS, fluorescence-activated cell sorting   FITC, fluorescein isothiocyanate   GAPDH, glyceraldehyde 3-phosphate dehydrogenase   HCC, hepatocellular carcinoma   Hh, hedgehog   PCNA, proliferating cell nuclear antigen   TGF-β1, transforming growth factor-β1
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