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The rs1801278 G>A polymorphism of IRS-1 is associated with metabolic syndrome in healthy nondiabetic men. Modulation by cigarette smoking status |
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| Authors: | Pérez María Silvia Tellechea Mariana L Aranguren Florencia Taverna Mariano J Rodríguez Ricardo G Meroño Tomás Brites Fernando Poskus Edgardo Frechtel Gustavo D |
| Affiliation: | aLaboratory of Molecular Biology, Department of Genetics and Molecular Biology, School of Pharmacy and Biochemistry, University of Buenos Aires (UBA), Argentina;bHumoral Immunity Institute “Prof. Ricardo A. Margni” (IDEHU), National Research Council (CONICET), Argentina;cDivision of Diabetology, Clinical Hospital “José de San Martín”, University of Buenos Aires (UBA), Argentina;dDiabetes Genetics Section of the Division of Genetics, Clinical Hospital “José de San Martín”, University of Buenos Aires (UBA), Argentina;eLaboratory of Lipids and Lipoproteins, Department of Clinical Biochemistry, School of Pharmacy and Biochemistry, University of Buenos Aires (UBA) and National Research Council of Argentina (CONICET), Argentina;fChair of Immunology, School of Pharmacy and Biochemistry, University of Buenos Aires, Argentina |
| Abstract: | AimsTo explore associations between IRS-1 rs1801278 G > A polymorphism and metabolic syndrome (MS).Methodsrs1801278 G > A was genotyped in 610 healthy Argentinian men.ResultsGA carriers had lower risk of MS (OR = 0.52, P = 0.045), particularly among smokers (OR = 0.10, P = 0.006).Conclusionsrs1801278 GA carriers had lower risk of MS, especially among smokers. |
| Keywords: | Genetics Insulin receptor substrate-1 Insulin resistance Metabolic syndrome Polymorphism Smoking Tobacco |
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