正常大肠,癌旁粘膜及癌表面扫描电镜观察

本文应用扫描电子显微镜并结合组织学检查,对20例正常大肠粘膜,癌旁粘膜,不同组织类型的癌组织表面进行了观察。正常大肠粘膜的表面超微结构是隐窝分布均匀,排列整齐,覆盖着吸收细胞和杯状细胞。癌旁粘膜表面隐窝结构有不同程度的变形,杯状细胞增多、增大。癌组织表面癌细胞形态特征与深部组织学类型有一定联系,尤其是癌细胞排列不规则及表面微绒毛数量减少,反映了癌组织的分化程度。作者认为应用扫描电镜观察可作为判断大肠癌分化程度的参考指标。

Superficial Ultrastructure of Normal Colorectal Mucosa, Juxtacancerous Mucosa and Cancerous Mucosa under Scanning Electron Microscopy

Twenty specimens of normal colorectal mucosa,juxtacancerous mucosa,and cancerous mucosa were studied with scanning electron microscopy,optical microscopy and histochemical method.It was found that the superficial crypts of normal colorectal mucosa were evenly distributed,orderly arranged,and covered with both absorptive cells and gobler cells;those of juxtacancerous mucosa were usually deformed in various degrees and their goblet cells were increased in number and in size;and the shape of the superficial cells of colorectal carcinoma was dependent on the histologic type of the carcinoma in certain extent.The general features were disordered arrangement and the decrease in number of the cellular microvilli,which indicated the malignant nature of the lesion.It is believed that scanning electron microscope is a useful tool in the diagnosis of colorectal carcinoma