| 大鼠全脑缺血脑组织钙,镁及钙调素含量变化及尼莫地平的影响 |
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| 引用本文： | 陈康宁 李露斯. 大鼠全脑缺血脑组织钙,镁及钙调素含量变化及尼莫地平的影响[J]. 第三军医大学学报, 1991, 13(6): 565-568 |
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| 作者姓名： | 陈康宁 李露斯 |
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| 作者单位： | 第三军医大学西南医院神经内科 630038(陈康宁，李露斯)，第三军医大学西南医院神经内科 630038(郑彩梅) |
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| 摘 要： | 本实验用大鼠全脑缺血模型测定了缺血再灌流中脑组织、线粒体钙镁含量变化及皮层、海马钙调素含量变化及尼莫地平对上述的影响。结果发现在缺血、再灌期镁含量明显减低,钙调素含量明显增高,再灌期钙含量明显增加。钙含量增加主要发生在再灌期,推测再灌流损伤与钙跨膜内流有关。尼莫地平能阻滞上述变化,从而对缺血再灌流损伤有保护作用。
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| 关 键 词： | 脑缺血 线粒体 尼莫地平 钙 镁 |
Effects of nimodipine on the changes of calcium, magnesium and calmodulin contents after cerebral ischemia in rats |
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| Chen Kangning,Li Lushi,Zhen Caimei. Effects of nimodipine on the changes of calcium, magnesium and calmodulin contents after cerebral ischemia in rats[J]. Acta Academiae Medicinae Militaris Tertiae, 1991, 13(6): 565-568 |
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| Authors: | Chen Kangning Li Lushi Zhen Caimei |
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| Abstract: | The changes of calcium and magnesium content in brain tissue (BCa;BMg) and in the mitochondria (MCa,MMg) and calmodulin content in the cortex and hippocampus (CCaM,HCaM) were determined in the rats with 4-vessel-ligation cerebral ischemia.And then the therapeutic effects of nimodipine were observed during ischemic and.reperfusion stages of the brain.It was found that BMg and BMg were decreased and CCaM HCaM increased during both the ischemic and reperfusion stages and BCa and MCo were increased during the reperfusion stage.The fact that calcium content was only increased during the reperfusion stage indicates that the influx of calcium plays an important role to precipitate injury during the reperfusion stage.Adminstration of nimodipine could prevent the increase of calcium and calmodulin and the decrease of magnesium after cerebral ischemia. |
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| Keywords: | cerebral ischemia reperfusion brain mitochondrium calcium magnesium calmodulin nimodipine |
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