Adaptive cellular protection against UVA-1-induced lipid peroxidation in human dermal fibroblasts shows donor-to-donor variability and is glutathione dependent |
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| Authors: | Lars Alexander Schneider Joachim Dissemond Peter Brenneisen Adelheid Hainzl Karlis Briviba Meinhard Wlaschek Karin Scharffetter-Kochanek |
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| Affiliation: | (1) Department of Dermatology and Allergology, University of Ulm, Maienweg 12, 89081 Ulm-Söflingen, Germany;(2) Department of Biochemistry & Molecular Biology I, University of Düsseldorf, Düsseldorf, Germany;(3) Department of Dermatology, University of Essen, Essen, Germany;(4) Federal Research Centre for Nutrition and Food, Karlsruhe, Germany |
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| Abstract: | Photo-oxidative stress and subsequent lipid peroxidation (LPO) is one of the major mechanisms of UVA-related skin pathology. The skin's protection system against photo-oxidative stress involves low molecular scavengers as well as highly specialised antioxidant enzymes like glutathione peroxidase (GPX). Against repetitive UVA-1 exposures in vitro it is partly adaptive, as recent studies have shown exemplarily for antioxidant enzymes. We now investigated in vitro by repetitively irradiating human dermal fibroblasts with UVA-1 whether this adaptive response might reflect itself in reduced cellular membrane damage, that is, LPO. Our experiments show that the degree of cellular protection against LPO and the adaptive potential of the cells against a repetitive UVA-1 exposure varies from donor-to-donor and depends highly on glutathione. |
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| Keywords: | Lipid peroxidation UVA Fibroblast Glutathione BSO GPX Malondialdehyde |
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