CD44s和CD44v6在涎腺腺样囊性癌中的表达

目的 研究细胞粘附分子ＣＤ４４ｓ及其剪接变异体ＣＤ４４ｖ６在涎腺腺样囊性癌中的表达，探讨ＣＤ４４ｖ６与ＡＣＣ生物学特性之间的关系。方法 采用免疫组化方法对５０例涎腺ＡＣＣ标本和１０例正常涎腺组织进行ＣＤ４４ｓ和ＣＤ４４ｖ６的检测。结果 （１）ＣＣＤ４４ｓ和ＣＤ４４ｖ６在正常涎腺组织均为阳性表达；在５０例ＡＣＣ标本中ＣＤ４４ｓ阳性率为５８％，ＣＤ４４ｖ６阳性率为７０％。（２）涎腺ＡＣＣ筛状型，管状型

The expression of CD44s and CD44v6 in human salivary adenoid cystic carcinoma *

OBJECTIVE:The present study was to investigate the expression of CD44s and CD44v6 in human salivary adenoid cystic carcinoma (ACC) and to discuss the relationship between the expression of the proteins and the biological characteristic of ACC.METHODS:Formalin fixed,paraffin embedded sections in 10 cases of normal salivary glands and 50 cases of human salivary ACC were examined using immunostaining for CD44s and CD44v6.RESULTS:(1)Positive signals of CD44s and CD44v6 were detected in all the specimens of normal salivary glands.Positive signals of CD44s and CD44v6 were detected in 29(58%) and 35(70%) of the 50 cases of ACC.(2)The expression of CD44s and CD44v6 in the solid pattern of ACC was significantly less than that in the cribriform and tubular pattern of ACC(P<0.05).(3)Positive CD44s staining was detected in 3(13.6%) of the 22 ACC primary sites which had a local recurrence after operation.CONCLUSION:(1)Adhesion molecules including CD44s and CD44v6 may contribute to maintain the normal structures in salivary gland tissues.(2)T he down-regulation or loss of CD44s expression was contributed to the recurrence of human salivary ACC and CD44s could be regarded as one of the factors to evaluate the prognosis of ACC patients.