| 清热合剂体外抗呼吸道合胞病毒作用 |
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| 引用本文： | 肇丽梅,张岩,韩国柱. 清热合剂体外抗呼吸道合胞病毒作用[J]. 中国实验方剂学杂志, 2006, 12(1): 53-55 |
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| 作者姓名： | 肇丽梅 张岩 韩国柱 |
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| 作者单位： | 1. 中国医科大学第二附属医院,辽宁,沈阳,110004
2. 大连医科大学,辽宁,大连,116027 |
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| 摘 要： | 目的：了解清热合剂对呼吸道合胞病毒（RSV）的抑制作用。方法：采用细胞培养技术，以双黄连为阳性对照药，观察清热合剂在非洲绿猴肾细胞（VERO）和咽喉癌上皮细胞（HEP-2）细胞中对RSV的抑制作用。结果：在VERO细胞中，清热合剂半数中毒浓度（TD50）为31．62mg／mL，抗合胞病毒的半数有效浓度（IC50）为0．50mg／mL，治疗指数（33）为63．24；在HEP-2细胞中，TD50为32．10mg／mL，抗合胞病毒的IC50为0．54mg／mL，TI为59．44。且对RSV抑制作用存在明显的量效反应关系（P〈0．01）。结论：清热合剂在VERO和HEP-2细胞中对RSV有明显抑制作用。
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| 关 键 词： | 呼吸道合胞病毒 抗病毒作用 清热合剂 |
| 文章编号： | 1005-9903（2006）00-0053-03 |
| 收稿时间： | 2004-12-24 |
| 修稿时间： | 2004-12-24 |
The Anti-respiratory Syncyntial Virus Effect of Qing Re He Ji |
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| ZHAO Li-mei,ZHANG Yan,HAN Guo-zhu. The Anti-respiratory Syncyntial Virus Effect of Qing Re He Ji[J]. China Journal of Experimental Traditional Medical Formulae, 2006, 12(1): 53-55 |
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| Authors: | ZHAO Li-mei ZHANG Yan HAN Guo-zhu |
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| Affiliation: | 1. The Second Hospital of Chinese Medical University, Liaoning Shenyang 110004, China ; 2. Dalian Medical University, Liaoning Dalian 116027, China |
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| Abstract: | Objective:To observe the anti-respiratory syncyntial virus(RSV) effect of Qing Re He Ji(QRHJ).Methods:The anti-RSV effect of QRHJ was observed by means of the technique of VERO and HEP-2 cell culture using Shuang Huang Lian as a positive control.Results:In VERO and HEP-2 cell culture,QRHJ was a potential inhibitor of RSV in concentration-dependent manner(P<0.01).The TD_(50) was 31.62mg/mL,the IC_(50) was 0.50mg/mL and TI was 63.24 in VERO cell culture.The TD_(50) was 32.10mg/mL,the IC50 was 0.54mg/mL and TI was 59.44 in HEP-2 cell culture.Conclusion:QRHJ has a significant anti-RSV effect in VERO and HEP-2 cell culture. |
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| Keywords: | respiratory syncyntial vires anti-viral effect Qing Re He Ji |
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