Appearance of focal cortical dysplasia on serial MRI after maturation of myelination |
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| Authors: | Fumiaki Yoshida Takato Morioka Kimiaki Hashiguchi Yasushi Miyagi Shinji Nagata Yui Yamaguchi Masaharu Ohfu Tomio Sasaki |
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| Institution: | (1) Department of Neurosurgery, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka 812-8582, Japan;(2) Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi Higashi-ku, Fukuoka 812-8582, Japan;(3) Department of Pediatrics, Fukuoka University, 7-45-1 Nanakuma Jonan-ku, Fukuoka 814-0180, Japan |
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| Abstract: | Case report It is well known that magnetic resonance imaging (MRI) findings of focal cortical dysplasia (FCD) can change with maturation
of myelination. In this paper, we report a patient with intractable epilepsy and negative MRI at the age of 2.5 years, after
completion of myelination. Follow-up MRI at the age of 6 years revealed typical FCD findings in the right frontal lobe. During
these 3.5 years, electroencephalogram (EEG) consistently depicted an area of irritation in accordance with de novo MRI findings.
Intraoperative electrocorticogram showed frequent paroxysmal activity in the right frontal lobe; excision of the epileptogenic
cortex resulted in a reduction in seizures.
Conclusion It is possible that FCD becomes apparent on MRI even after maturation of myelination; thus, repeated MRI is recommended while
EEG continues to demonstrate focal findings. |
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| Keywords: | Focal cortical dysplasia Magnetic resonance imaging Myelination Electroencephalography Epilepsy Development |
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