Association of HLA Antigens with Glucose Intolerance Following Renal Transplantation |
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| Authors: | A. J. F. d''Apice J. D. Mathews B. D. Tait Priscilla Kincaid-Smith |
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| Affiliation: | Department of Nephrology, Tissue Typing Laboratory and The University of Melbourne Department of Medicine, The Royal Melbourne Hospital, Victoria Australia |
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| Abstract: | Records of 109 renal transplant patients were reviewed to test the hypothesis that post transplant glucose intolerance would be associated with "diabetic", HLA antigens (HLA--B8, B18, Bw15 and Bw16). Of 42 patients with significant glucose intolerance, 23 had one or more of these antigens (RR=2.65, P=0.01). These findings suggest that stress or drug treatment associated with renal transplantation can induce glucose intolerance in patients with a "diabetic" gene associated with the HLA--B locus. |
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